The cross-reactive idiotype of A-strain mice Serological and structural analyses.
The cross-reactive idiotype of A-strain mice Serological and structural analyses.
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A 品系小鼠的交叉反应独特型血清学和结构分析。
DOI：
10.1016/0167-5699(82)90018-4
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Philip W. Tucker
中科院分区：
文献类型：
--
作者：
J. Capra;Clive Slaughter;Eric C.B. Milner;P. Estess;Philip W. Tucker
独特型参与了复杂的体液和细胞介导的免疫现象的诱导和调节。现在，随着杂交瘤技术的发展，独特型的分子基础之谜正在屈服于系统的血清学和结构分析。在这里，Don Capra和他的同事描述了最近对一种最著名的独特型系统的研究，即对arsonate的抗体反应。像免疫学中的许多东西一样，独特型最初是由血清学定义的。独立地，Oudin和KunkeP， 2描述了免疫球蛋白的独特抗原决定因子，它们成为单个分子或相关分子群的标记。这些决定因素后来定位于重多肽链和轻多肽链的可变区域。随后，大量证据积累了与抗体结合位点和高变区相关的独特型3。Jerne 4的网络假说通过提出免疫球蛋白分子的这些独特方面实际上完整地参与免疫系统的正常生理调节，将独特型带入了免疫学的主流。在家兔身上证明了独特型可以遗传之后，大多数的信号观察都是在小鼠身上进行的，目前绝大多数的独特型分析都是在近交系小鼠身上进行的。早期出现了两种截然不同的系统：一种是基于已知的具有特定结合活性的骨髓瘤蛋白（例如，al， 3葡聚糖和磷酸胆碱），另一种是基于诱导抗体反应（例如对偶氮苯基larsonate和4-羟基-3-硝基苯基acetyl）。这两种系统的根本区别在于，前者是基于一种均质抗体（骨髓瘤），而后者是基于免疫反应，后者虽然相对均质，但在抗原刺激下产生的抗体谱。
Idiotypes have been implicated in the induction and regulation of complex humoral and cell-mediated immune phenomena. Now, with the development of hybridoma technology, the enigma of the molecular basis of idiotypy is succumbing to systematic serological and structural analyses. Here Don Capra and his colleagues describe recent studies on one of the best known idiotype systems, in the antibody response to arsonate.Like many things m immunology, idiotypes were defined originally by serology. Independently, Oudin and KunkeP, 2 described unique antigenic determinants of immunoglobulins which became markers of individual molecules or groups of related molecules. These determinants were later localized to the variable regions of the heavy and light polypeptide chains. Subsequently, a large body of evidence accumulated relating idiotypy with the antibody combining site and the hypervariable regions 3. The network hypothesis of Jerne 4 brought idiotypes into the mainstream of immunology by proposing that these unique aspects of immunoglobulin molecules were, in fact, integrally involved in the normal, physiological regulation of the immune system. After the demonstration in tile rabbit s that idiotypes could be inherited, most of the signal observations have been made in the mouse and the vast majority of idiotypic analyses at the prfisent time are done in inbred murine strains. Two distinctly different systems emerged early: those based on the known myeloma proteins with specific binding activities (for example, al, 3 dextran and phosphorylcholine) and those based on induced antibody responses (such as to p-azophenylarsonate and 4-hydroxy-3-nitrophenyl acetyl). These two kinds of systems differed fundamentally in that the former was based on a homogeneous antibody (myeloma) while the latter was based on immune responses which, while relatively homogeneous, presented a spectrum of antibodies made in response to an antigenic stimulus.
免疫球蛋白重链可变部分基因的体细胞突变。
DOI：
10.1126/science.6801765
发表时间：
1982
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Sims,J;Rabbitts,TH;Estess,P;Slaughter,C;Tucker,PW;Capra,JD
通讯作者：
Capra,JD
A/J 小鼠抗对偶氮苯胂酸单克隆抗体的结构多样性；
影响因子：
3.6
作者：
Margolies,MN;Marshak-Rothstein,A;Gefter,ML
通讯作者：
Gefter,ML
对偶氮苯胂酸抗体反应中的 VH 家族：血清学与氨基酸序列之间的相关性。
DOI：
--
发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Milner,EC;Capra,JD
通讯作者：
Capra,JD