Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases.
Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases.
复制标题
血清甲基丙二酸水平升高与心血管疾病的存在相关
DOI：
10.3389/fcvm.2022.966543
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发表时间：
2022
影响因子：
3.6
通讯作者：
Xiang, Meixiang
中科院分区：
文献类型：
--
作者：
Wang, Xiaoya;Li, Wudi;Xiang, Meixiang
功能性维生素B12缺乏症在心血管疾病（CVD）中很常见，如心力衰竭和心肌梗死。甲基丙二酸（MMA）是维生素B12缺乏的特异性和敏感性标志物。然而，关于MMA和CVD之间的关系的数据很少。在这项横断面研究中，我们分析了2013-2014年国家健康和营养调查（NHANES）的5，313名成年参与者的数据。MMA和其他变量之间的关联进行了评估与线性回归模型。采用单变量和多变量logistic回归模型探讨MMA与CVD之间的关系。美国一般人群中CVD的加权患病率为8.8%。在CVD参与者中发现较高的MMA水平（p < 0.001）。线性回归模型显示，血清MMA水平与年龄（p < 0.001）、糖化血红蛋白（p = 0.023）、空腹血糖（p = 0.044）、平均细胞体积（p = 0.038）和高血压（p = 0.003）呈正相关。在校正年龄、性别、种族、吸烟、高血压、糖化血红蛋白、体重指数（BMI）、低密度脂蛋白胆固醇（LDL-C）、肾功能不全和维生素B12的多变量logistic模型中，血清MMA（校正比值比，3.08; 95%置信区间：1.63-5.81，p = 0.002，每ln nmol/L增量）与CVD相关。我们的研究表明，血清MMA水平升高与心血管疾病的存在独立相关，并可用于预测心血管疾病的发生。
Functional vitamin B12 deficiency is common in cardiovascular diseases (CVDs), such as heart failure and myocardial infarction. Methylmalonic acid (MMA) is a specific and sensitive marker of vitamin B12 deficiency. However, there are scarce data in regard to the relationship between MMA and CVDs. In this cross-sectional study, we analyzed data of 5,313 adult participants of the National Health and Nutrition Examination Survey (NHANES) 2013–2014. Associations between MMA and other variables were assessed with linear regression models. Univariable and multivariable logistic regression models were employed to explore the association between MMA and CVDs. The weighted prevalence of CVDs was 8.8% in the general population of the USA. Higher MMA levels were found in participants with CVDs (p < 0.001). Linear regression models revealed positive associations between serum MMA level and age (p < 0.001), glycohemoglobin (p = 0.023), fasting glucose (p = 0.044), mean cell volume (p = 0.038), and hypertension (p = 0.003). In the multivariable logistic model adjusting for age, gender, ethnicity, smoking, hypertension, glycohemoglobin, body mass index (BMI), low-density lipoprotein-cholesterol (LDL-C), renal dysfunction and vitamin B12, serum MMA (adjusted odds ratio, 3.08; 95% confidence interval: 1.63–5.81, p = 0.002, per ln nmol/L increment) was associated with CVDs. Our study demonstrated that elevated serum MMA levels were independently associated with the presence of CVDs and may be used to predict the occurrence of CVDs.
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影响因子：
120.7
作者：
Armitage, Jane M.;Bowman, Louise;Collins, Rory
通讯作者：
Collins, Rory
DOI：
10.1111/j.1365-2362.2010.02430.x
发表时间：
2011-04-01
影响因子：
5.5
作者：
Mizukami, Hiroki;Ogasawara, Saori;Yagihashi, Soroku
通讯作者：
Yagihashi, Soroku
影响因子：
4.8
作者：
Okun, JG;Hörster, F;Kölker, S
通讯作者：
Kölker, S
影响因子：
81.5
作者：
Green, Ralph;Allen, Lindsay H.;Yajnik, Chittaranjan
通讯作者：
Yajnik, Chittaranjan
影响因子：
9.8
作者：
Dierkes, J;Domröse, U;Luley, C
通讯作者：
Luley, C