Mitochondrial DNA, nuclear context, and the risk for carcinogenesis.
Mitochondrial DNA, nuclear context, and the risk for carcinogenesis.
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DOI：
10.1002/em.22169
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发表时间：
2019-06
影响因子：
2.8
通讯作者：
Sondheimer N
中科院分区：
文献类型：
--
作者：
Kaufman BA;Picard M;Sondheimer N
线粒体DNA（mtDNA）从母亲到孩子的遗传由于线粒体基因组稳定性的差异而变得复杂。虽然生殖系mtDNA通过最小化世代之间的复制而得到保护，但序列变异可以通过突变或由于母亲中存在的不同基因组之间的比例变化而发生（称为异质性）。因此，线粒体DNA跨代遗传的不可预测性可能会导致后代出现致病性线粒体和细胞表型。关于线粒体代谢在癌症中的作用的研究有着悠久而丰富的历史，但最近的证据强烈表明，线粒体基因型和表型的变化在癌症的发生、进展和治疗中起着重要作用。在这两个领域的交叉点，存在着新出现的mtDNA突变驱动后代致癌的可能性。在这篇综述中，我们认为，这方面的跨代致癌作用仍然未充分探索，是一个潜在的重要贡献者癌症。
The inheritance of mitochondrial DNA (mtDNA) from mother to child is complicated by differences in the stability of the mitochondrial genome. Although the germ line mtDNA is protected through the minimization of replication between generations, sequence variation can occur either through mutation or due to changes in the ratio between distinct genomes that are present in the mother (known as heteroplasmy). Thus, the unpredictability in transgenerational inheritance of mtDNA may cause the emergence of pathogenic mitochondrial and cellular phenotypes in offspring. Studies of the role of mitochondrial metabolism in cancer have a long and rich history, but recent evidence strongly suggests that changes in mitochondrial genotype and phenotype play a significant role in the initiation, progression and treatment of cancer. At the intersection of these two fields lies the potential for emerging mtDNA mutations to drive carcinogenesis in the offspring. In this review, we suggest that this facet of transgenerational carcinogenesis remains underexplored and is a potentially important contributor to cancer.
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影响因子：
56.9
作者：
Fan, Weiwei;Waymire, Katrina G.;Wallace, Douglas C.
通讯作者：
Wallace, Douglas C.
DOI：
10.1042/bj20130029
发表时间：
2013-10-15
期刊：
The Biochemical journal
影响因子：
--
作者：
Fetterman JL;Zelickson BR;Johnson LW;Moellering DR;Westbrook DG;Pompilius M;Sammy MJ;Johnson M;Dunham-Snary KJ;Cao X;Bradley WE;Zhang J;Wei CC;Chacko B;Schurr TG;Kesterson RA;Dell'italia LJ;Darley-Usmar VM;Welch DR;Ballinger SW
通讯作者：
Ballinger SW
影响因子：
7.7
作者：
Ju YS;Alexandrov LB;Gerstung M;Martincorena I;Nik-Zainal S;Ramakrishna M;Davies HR;Papaemmanuil E;Gundem G;Shlien A;Bolli N;Behjati S;Tarpey PS;Nangalia J;Massie CE;Butler AP;Teague JW;Vassiliou GS;Green AR;Du MQ;Unnikrishnan A;Pimanda JE;Teh BT;Munshi N;Greaves M;Vyas P;El-Naggar AK;Santarius T;Collins VP;Grundy R;Taylor JA;Hayes DN;Malkin D;ICGC Breast Cancer Group;ICGC Chronic Myeloid Disorders Group;ICGC Prostate Cancer Group;Foster CS;Warren AY;Whitaker HC;Brewer D;Eeles R;Cooper C;Neal D;Visakorpi T;Isaacs WB;Bova GS;Flanagan AM;Futreal PA;Lynch AG;Chinnery PF;McDermott U;Stratton MR;Campbell PJ
通讯作者：
Campbell PJ
影响因子：
9.8
作者：
Brown, DT;Samuels, DC;Chinnery, PF
通讯作者：
Chinnery, PF
与成年线粒体疾病有关的核和线粒体DNA突变的患病率。
影响因子：
11.2
作者：
Gorman GS;Schaefer AM;Ng Y;Gomez N;Blakely EL;Alston CL;Feeney C;Horvath R;Yu-Wai-Man P;Chinnery PF;Taylor RW;Turnbull DM;McFarland R
通讯作者：
McFarland R