Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger.
Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger.
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DOI：
10.1007/s10549-011-1616-x
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发表时间：
2011-11
影响因子：
3.8
通讯作者：
Bernstein JL
中科院分区：
文献类型：
--
作者：
Gaudet MM;Press MF;Haile RW;Lynch CF;Glaser SL;Schildkraut J;Gammon MD;Douglas Thompson W;Bernstein JL
发病率，预后和治疗反应的差异表明基因表达模式可以识别具有独特风险因素特征的乳腺癌亚型;然而，以前的结果主要基于老年女性。在这项研究中，我们研究了≤56岁的女性中相似的关系，通过对890例乳腺癌病例和3，432例频率匹配的基于人群的对照进行雌激素受体、孕激素受体和人表皮生长因子受体-2的免疫组织化学染色进行分类。采用多元多分类回归模型计算肿瘤亚型的比值比（OR）和95%置信区间（CI）。共有455例（51.1%）肿瘤被认为是管腔A型，72例（8.1%）为管腔B型，117例（13.1%）为非管腔HER-2/neu+型，246例（27.6%）为三阴性。三阴性肿瘤与母乳喂养持续时间相关（每6个月：OR = 0.76，95%CI 0.64-0.90）。在绝经前女性中，体型增加与管腔型B（OR = 1.73，95% CI 1.07-2.77）和三阴性肿瘤（OR = 1.67，95% CI 1.22-2.28）的相关性更强。良性乳腺疾病史仅与管腔A型肿瘤风险增加相关（OR = 1.89，95%CI 1.43-2.50）。乳腺癌家族史是管腔A型肿瘤的危险因素（OR = 1.93，95%CI 1.38-2.70），与年龄无关，三阴性肿瘤对于<45岁的女性具有更高的风险（OR = 5.02，95%CI 2.82-8.92;年龄相互作用P = 0.005）。我们发现，几乎没有母乳喂养和高BMI与三阴性乳腺癌的风险增加有关。一些危险因素因分子亚型不同而不同，提示年轻女性乳腺癌发生的病因异质性。
Differences in incidence, prognosis, and treatment response suggest gene expression patterns may discern breast cancer subtypes with unique risk factor profiles; however, previous results were based predominantly on older women. In this study, we examined similar relationships in women ≤56 years, classified by immunohistochemical staining for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 for 890 breast cancer cases and 3,432 frequency-matched population-based controls. Odds ratios (OR) and 95% confidence intervals (CI) for tumor subtypes were calculated using multivariate polytomous regression models. A total of 455 (51.1%) tumors were considered luminal A, 72 (8.1%) luminal B, 117 (13.1%) non-luminal HER-2/neu+,and 246 (27.6%) triple negative. Triple negative tumors were associated with breast feeding duration (per 6 months: OR = 0.76, 95% CI 0.64–0.90). Among pre-menopausal women, increasing body size was more strongly associated with luminal B (OR = 1.73, 95% CI 1.07–2.77) and triple negative tumors (OR = 1.67, 95% CI 1.22–2.28). A history of benign breast disease was associated only with increased risk of luminal A tumors (OR = 1.89, 95% CI 1.43–2.50). A family history of breast cancer was a risk factor for luminal A tumors (OR = 1.93, 95% CI 1.38–2.70) regardless of age, and triple negative tumors with higher risks for women <45 (OR = 5.02, 95% CI 2.82–8.92; P for age interaction = 0.005). We found that little-to-no breastfeeding and high BMI were associated with increased risk of triple negative breast cancer. That some risk factors differ by molecular subtypes suggests etiologic heterogeneity in breast carcinogenesis among young women.
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影响因子：
11.5
作者：
Carey, Lisa A.;Dees, E. Claire;Perou, Charles M.
通讯作者：
Perou, Charles M.
影响因子：
3.8
作者：
Lund, Mary Jo;Trivers, Katrina F.;Eley, J. William
通讯作者：
Eley, J. William
影响因子：
3.8
作者：
Millikan, Robert C.;Newman, Beth;Perou, Charles M.
通讯作者：
Perou, Charles M.
影响因子：
10.3
作者：
Brinton, Louise A.;Sherman, Mark E.;Anderson, William F.
通讯作者：
Anderson, William F.
影响因子：
5
作者：
DiVito, KA;Charette, LA;Camp, RL
通讯作者：
Camp, RL