Estimating the impact of Tiny Targets in reducing the incidence of Gambian sleeping sickness in the North-west Uganda focus.
Estimating the impact of Tiny Targets in reducing the incidence of Gambian sleeping sickness in the North-west Uganda focus.
复制标题
DOI：
10.1186/s13071-021-04889-x
复制
发表时间：
2021-08-18
影响因子：
3.2
通讯作者：
Hope A
中科院分区：
文献类型：
--
作者：
Bessell PR;Esterhuizen J;Lehane MJ;Longbottom J;Mugenyi A;Selby R;Tirados I;Torr SJ;Waiswa C;Wamboga C;Hope A
河栖采采蝇（舌蝇属）传播冈比亚布氏锥虫，导致冈比亚人非洲锥虫病（gHAT），这是一种被忽视的热带疾病。乌干达的目标是通过发现和治疗人间病例以及病媒控制，消除作为公共卫生问题的gHAT。后者是通过部署“微小目标”来实现的，这是一种吸引和杀死采采蝇的材料浸渍板。我们分析了2010-2019年期间乌干达gHAT病例的空间和时间分布，以评估微小目标是否对疾病发病率产生影响。为了量化微小目标的部署，我们绘制了干预区域的河流及其相关流域。然后，我们根据微小目标是否不存在（0），仅存在于邻近流域（1），存在于流域但不是所有邻居（2），或存在于流域和所有邻居（3），将它们分为0-3级。我们覆盖了2000年至2020年期间诊断的所有病例，并评估了在目标部署后，在分水岭中发现病例的概率是否发生了变化。我们还估计了通过控制采采蝇避免的病例数。我们发现，在分水岭中部署微小目标后，HAT的情况较少，抽样误差概率为0.007。我们估计，在2012-2019年的干预期间，我们应该预期有48例（95%置信区间= 40-57），而观察到的病例为36例。结果对一系列敏感性分析具有稳健性。在乌干达西北部，微小目标使gHAT的发病率降低了25%。在线版本包含补充材料，可通过10.1186/s13071-021-04889-x获得。
Riverine species of tsetse (Glossina) transmit Trypanosoma brucei gambiense, which causes Gambian human African trypanosomiasis (gHAT), a neglected tropical disease. Uganda aims to eliminate gHAT as a public health problem through detection and treatment of human cases and vector control. The latter is being achieved through the deployment of ‘Tiny Targets’, insecticide-impregnated panels of material which attract and kill tsetse. We analysed the spatial and temporal distribution of cases of gHAT in Uganda during the period 2010–2019 to assess whether Tiny Targets have had an impact on disease incidence. To quantify the deployment of Tiny Targets, we mapped the rivers and their associated watersheds in the intervention area. We then categorised each of these on a scale of 0–3 according to whether Tiny Targets were absent (0), present only in neighbouring watersheds (1), present in the watersheds but not all neighbours (2), or present in the watershed and all neighbours (3). We overlaid all cases that were diagnosed between 2000 and 2020 and assessed whether the probability of finding cases in a watershed changed following the deployment of targets. We also estimated the number of cases averted through tsetse control. We found that following the deployment of Tiny Targets in a watershed, there were fewer cases of HAT, with a sampled error probability of 0.007. We estimate that during the intervention period 2012–2019 we should have expected 48 cases (95% confidence intervals = 40–57) compared to the 36 cases observed. The results are robust to a range of sensitivity analyses. Tiny Targets have reduced the incidence of gHAT by 25% in north-western Uganda. The online version contains supplementary material available at 10.1186/s13071-021-04889-x.
登录
查看更多内容
在刚果民主共和国金刚省中部省的甘戈人非洲锥虫病的加强筛查战略的制定和实施。
影响因子：
3.8
作者：
Lumbala C;Kayembe S;Makabuza J;Lutumba P;Van Geertruyden JP;Bessell PR;Ndung'u JM
通讯作者：
Ndung'u JM
影响因子：
3.7
作者：
Bessell PR;Lumbala C;Lutumba P;Baloji S;Biéler S;Ndung'u JM
通讯作者：
Ndung'u JM
影响因子：
3.8
作者：
Lehane M;Alfaroukh I;Bucheton B;Camara M;Harris A;Kaba D;Lumbala C;Peka M;Rayaisse JB;Waiswa C;Solano P;Torr S
通讯作者：
Torr S
影响因子：
3.8
作者：
Selby, Richard;Wamboga, Charles;Lehane, Michael
通讯作者：
Lehane, Michael
影响因子：
3.8
作者：
Tirados I;Hope A;Selby R;Mpembele F;Miaka EM;Boelaert M;Lehane MJ;Torr SJ;Stanton MC
通讯作者：
Stanton MC