Diagnostic accuracy of research criteria for prodromal frontotemporal dementia.
Diagnostic accuracy of research criteria for prodromal frontotemporal dementia.
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DOI：
10.1186/s13195-024-01383-1
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发表时间：
2024-01-12
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遗传性额颞部倡议分期小组提出了前驱性额颞部痴呆(FTD)的临床诊断标准，称为轻度认知和/或行为和/或运动障碍(MCBMI)。这项研究的目的是在一组经基因确认的FTD病例与健康对照的队列中验证所提出的MCBMI-FTD研究标准。共有398名参与者入选，其中117人为临床症状轻微的FTD致病变异体携带者，281人为非携带者家庭成员(健康对照组)。一组患者接受了血液神经丝光(NFL)水平和前扣带回萎缩的评估。核心临床标准正确地将MCBMI与HC进行了分类，AUC值为0.79(p<；0.001)，而血液NFL或前扣带回萎缩显著增加了AUC值，分别为0.84和0.82(p<；0.001)。这两个标记物的加入使AUC值进一步增加到0.9(p<；0.001)。提出的MCBMI标准对FTD的前驱分期具有很好的分类准确性。网上版载有补充材料，可在10.1186/s13195-024-01383-1查阅。
The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI). The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls. A total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment. The core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (p < 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (p < 0.001). The addition of both markers further increased the AUC to 0.90 (p < 0.001). The proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD. The online version contains supplementary material available at 10.1186/s13195-024-01383-1.
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