Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes.
Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes.
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DOI：
10.3389/fphar.2011.00054
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发表时间：
2011
影响因子：
5.6
通讯作者：
Cummins TR
中科院分区：
文献类型：
--
作者：
Theile JW;Cummins TR
慢性和神经性疼痛构成严重的健康问题，每年影响数百万人。痛觉通常起源于外周神经系统的感觉神经元，将信息传递给中枢神经系统（CNS）。病理性痛觉的产生是这些外周感觉神经元兴奋性变化的结果。电压门控钠通道是调节动作电位产生和传播的关键决定因素；因此，钠通道功能的改变可能对神经元兴奋性和疼痛信号产生深远的影响。目前，临床上用于治疗疼痛的大多数钠通道阻滞剂是非选择性的，并且可能导致心脏毒性、运动障碍和中枢神经系统副作用。在过去的十年中，在开发更多选择性和有效的钠通道阻滞剂来治疗疼痛方面取得了许多进展。本综述的目的是强调研究型大学和制药公司在追求开发更有针对性的钠通道疗法以治疗各种神经性疼痛状况方面提出的一些最新进展。
Chronic and neuropathic pain constitute significant health problems affecting millions of individuals each year. Pain sensations typically originate in sensory neurons of the peripheral nervous system which relay information to the central nervous system (CNS). Pathological pain sensations can arise as result of changes in excitability of these peripheral sensory neurons. Voltage-gated sodium channels are key determinants regulating action potential generation and propagation; thus, changes in sodium channel function can have profound effects on neuronal excitability and pain signaling. At present, most of the clinically available sodium channel blockers used to treat pain are non-selective across sodium channel isoforms and can contribute to cardio-toxicity, motor impairments, and CNS side effects. Numerous strides have been made over the last decade in an effort to develop more selective and efficacious sodium channel blockers to treat pain. The purpose of this review is to highlight some of the more recent developments put forth by research universities and pharmaceutical companies alike in the pursuit of developing more targeted sodium channel therapies for the treatment of a variety of neuropathic pain conditions.
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影响因子：
8.8
作者：
Binshtok AM;Gerner P;Oh SB;Puopolo M;Suzuki S;Roberson DP;Herbert T;Wang CF;Kim D;Chung G;Mitani AA;Wang GK;Bean BP;Woolf CJ
通讯作者：
Woolf CJ
DOI：
10.1073/pnas.1005633107
发表时间：
2010-07-06
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
5
作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
5.5
作者：
Baker, MD;Chandra, SY;Wood, JN
通讯作者：
Wood, JN