Pathogenesis of IgE-mediated food allergy and implications for future immunotherapeutics.
Pathogenesis of IgE-mediated food allergy and implications for future immunotherapeutics.
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DOI：
10.1111/pai.13501
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Berin MC
中科院分区：
文献类型：
--
作者：
Ramsey N;Berin MC
我们对食物过敏的免疫基础的理解与治疗食物过敏的新免疫靶向干预措施的开发同步快速增长。局部组织因素，包括皮肤和胃肠道微生物群的组成以及来自屏障部位的Th 2诱导细胞因子（TSLP、IL-33和IL-25）的产生，已被证明不仅有助于食物过敏的发展，而且还可作为小鼠治疗的有效靶点。正在进行的临床试验正在测试这些因素在人类疾病中的靶向作用。越来越多的人认识到IL-13对高亲和力IgE诱导的作用，以及在维持长寿IgE中需要持续的T细胞帮助。这为测试靶向IL-4和IL-13的生物制剂治疗已建立的食物过敏提供了强有力的理论基础。食物过敏的各种形式的过敏原免疫疗法已经清楚地表明，低特异性IgE和升高的特异性IgG 4可预测持续的治疗效果。模拟这种免疫反应的治疗，例如，用单克隆抗体如奥马珠单抗降低IgE，或给予过敏原特异性IgG，正处于不同的研究阶段。随着我们有更多的机会使用免疫修饰治疗来治疗食物过敏，对这些干预措施的免疫和临床反应的研究将继续快速推进我们对食物过敏和耐受性的免疫基础的理解。
Our understanding of the immune basis of food allergy has grown rapidly in parallel with the development of new immune-targeted interventions for the treatment of food allergy. Local tissue factors, including the composition of skin and gastrointestinal microbiota and production of Th2-inducing cytokines (TSLP, IL-33, and IL-25) from barrier sites, have been shown not only to contribute to the development of food allergy, but also to act as effective targets for treatment in mice. Ongoing clinical trials are testing the targeting of these factors in human disease. There is a growing understanding of the contribution of IL-13 to the induction of high-affinity IgE and the need for continual T-cell help in the maintenance of long-lived IgE. This provides a strong rationale to test biologics targeting both IL-4 and IL-13 in the treatment of established food allergy. Various forms of allergen immunotherapy for food allergy have clearly shown that low specific IgE and elevated specific IgG4 are predictive of sustained treatment effect. Treatments that mimic that immune response, for example, lowering IgE, with monoclonal antibodies such as omalizumab, or administering allergen-specific IgG, are in various stages of investigation. As we gain more opportunities to use immune-modifying treatments for the treatment of food allergy, studies of the immune and clinical response to those interventions will continue to rapidly advance our understanding of the immune basis of food allergy and tolerance.
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影响因子：
14.2
作者：
Chiang, David;Chen, Xintong;Berin, M. Cecilia
通讯作者：
Berin, M. Cecilia
DOI：
10.1186/s13223-017-0223-8
发表时间：
2017
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
Andorf S;Manohar M;Dominguez T;Block W;Tupa D;Kshirsagar RA;Sampath V;Chinthrajah RS;Nadeau KC
通讯作者：
Nadeau KC
影响因子：
6.1
作者：
Gauvreau, G. M.;Boulet, L. -P.;O'Byrne, P. M.
通讯作者：
O'Byrne, P. M.
影响因子：
24.8
作者：
Asrat, Seblewongel;Kaur, Navneet;Orengo, Jamie M.
通讯作者：
Orengo, Jamie M.
影响因子：
120.7
作者：
Bachert, Claus;Mannent, Leda;Sutherland, E. Rand
通讯作者：
Sutherland, E. Rand