The inhibitor of DNA binding 2 is mainly expressed in oligodendrocyte lineage cells in adult rat brain
The inhibitor of DNA binding 2 is mainly expressed in oligodendrocyte lineage cells in adult rat brain
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DNA结合抑制剂2主要表达于成年大鼠脑中的少突胶质细胞系细胞
DOI：
10.1016/j.neulet.2007.09.044
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发表时间：
2007-11
影响因子：
2.5
通讯作者：
Yao, Zhong-Xiang
中科院分区：
文献类型：
--
作者：
Zhou, De-Shan;Chen, Xing-Shu;Yao, Zhong-Xiang
DNA结合抑制因子2（Inhibitor of DNA binding 2，Id 2）在胚胎发育和成年期的脑中起着重要作用。但在成年大鼠脑中，Id 2的免疫反应是否主要存在于神经元、星形胶质细胞和/或少突胶质细胞系细胞中尚不清楚。目前还不清楚Id 2免疫反应主要在少突胶质细胞系细胞中的位置和时间。本研究表明，90%的Id 2免疫反应性的少突胶质细胞系细胞在胼胝体，视交叉，脑桥的纵束，内侧隔核，海马伞，前连合，和锥体束等脑区。在星形胶质细胞中发现5%的Id 2免疫反应性。Id 2免疫反应仅分布于少数脑区的神经元。在CC-1阳性的成熟少突胶质细胞中发现70%的Id 2免疫反应性。这些观察结果表明，Id 2可能主要参与少突胶质细胞的终末成熟和髓鞘形成。
The inhibitor of DNA binding 2 (Id2) plays an important role in the brain both during embryogenesis and adulthood. But in adult rat brain, it is still unknown whether Id2 immunoreactivity mainly exhibits in neuronal, astrocytic and/or oligodendrocyte lineage cells. It is also unclear where and when Id2 immunoreactivity mainly exhibits in oligodendrocyte lineage cells. The present study showed 90% of Id2-immunoreactivity in oligdendrocyte lineage cells in such brain regions as the corpus callosum, optic chiasm, the longitudinal fasciculus of pons, the medial septal nucleus, the fimbria of hippocampus, the anterior commissure, and the pyramidal tract. Five percent of Id2-immunoreactivity was found in astrocytes. Id2 immunoreactivity was localized in neurons of only a few brain regions. Seventy percent of Id2 immunoreactivity was found in CC-1-positive mature oligodendrocytes. These observations suggest that Id2 may be mainly involved in terminal maturation of oligodendrocytes and myelination.
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影响因子：
4.8
作者：
Deed, RW;Armitage, S;Norton, JD
通讯作者：
Norton, JD
影响因子：
64.5
作者：
BENEZRA, R;DAVIS, RL;WEINTRAUB, H
通讯作者：
WEINTRAUB, H
DOI：
--
发表时间：
1967
期刊：
--
影响因子：
--
作者：
L. Pellegrino;A. Cushman
通讯作者：
L. Pellegrino;A. Cushman
影响因子：
8
作者：
Yokota, Y
通讯作者：
Yokota, Y
DOI：
10.1006/bbrc.1994.1380
发表时间：
1994-03-30
影响因子：
3.1
作者：
NAGATA, Y;TODOKORO, K
通讯作者：
TODOKORO, K