Integrated Histotripsy and Bubble Coalescence Transducer for Thrombolysis.
Integrated Histotripsy and Bubble Coalescence Transducer for Thrombolysis.
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DOI：
10.1016/j.ultrasmedbio.2018.08.013
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发表时间：
2018-12
影响因子：
2.9
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Shi A;Lundt J;Deng Z;Macoskey J;Gurm H;Owens G;Zhang X;Hall TL;Xu Z
在空化泡云崩溃之后，残留的微泡可以持续长达数秒，并且在称为空化记忆效应的现象中充当随后脉冲的弱空化核。在组织摧毁术中，空化记忆效应可导致气泡云在相同的离散部位重复形成。这种效应限制了基于组织分裂的组织分级的功效。我们以前的研究表明，低振幅气泡聚结（BC）的高振幅组织破碎脉冲之间的超声序列交错可以合并残留的气泡迅速成为一个大的气泡。这减少了空化记忆效应，并且可以增加治疗功效。已经研究了通过将凝块破碎成比红细胞更小的碎片来进行血栓溶解的组织破坏术。然而，这种治疗对老化或收缩的凝块的疗效较低。在这项研究中，我们研究了使用组织破碎术与BC，以提高治疗效果的回缩凝块。内部构建了一个集成的组织破碎和气泡凝聚（HBC）换能器系统，配有专用电子驱动系统。1个高振幅（32 MPa）、1个周期的组织破坏脉冲，随后是36个低振幅（2.4 MPa）、1个周期的BC脉冲，形成一个HBC序列。结果表明，在0.2 - 0.5 mm/s的扫描速度下，HBC序列成功地产生了通过收缩的凝块的流动通道。与单独使用组织破坏术相比，使用HBC序列创建的通道尺寸大128-480%。HBC治疗期间产生的凝块碎片颗粒在安全范围内。这些结果证实了BC改善了组织碎石溶栓对回缩凝块的治疗效果的概念。
Following the collapse of a cavitation bubble cloud, residual microbubbles can persist for up to seconds and function as weak cavitation nuclei for subsequent pulses in a phenomenon known as cavitation memory effect. In histotripsy, the cavitation memory effect can cause bubble clouds to repeatedly form at the same discrete set of sites. This effect limits the efficacy of histotripsy-based tissue fractionation. Our previous studies have shown that low-amplitude bubble coalescing (BC) ultrasound sequences interleaved between high-amplitude histotripsy pulses can coalescence the residual bubbles into one large bubble quickly. This reduces the cavitation memory effect and may increase treatment efficacy. Histotripsy has been investigated for thrombolysis by breaking up clots to debris smaller than red blood cells. However, this treatment has low efficacy for aged or retracted clot. In this study, we investigate the use of histotripsy with BC to improve the treatment efficacy for retracted clots. An integrated histotripsy and bubble coalescing (HBC) transducer system with specialized electronic driving system was built in-house. One high amplitude (32 MPa), 1-cycle histotripsy pulse followed by 36 low amplitude (2.4 MPa), 1-cycle BC pulses formed one HBC sequence. Results show that HBC sequences successfully generated a flow channel through the retracted clots under scan speeds of 0.2 – 0.5 mm/s. The created channel size was 128–480% larger using the HBC sequence compared to using histotripsy alone. The clot debris particles generated during HBC treatments were within the safe range. These results demonstrate the concept that BC improves treatment efficacy of histotripsy thrombolysis for retracted clots.
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影响因子：
8.3
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Lansberg MG;Bluhmki E;Thijs VN
通讯作者：
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通讯作者：
Xu, Zhen
影响因子：
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通讯作者：
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