Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2.
Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2.
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DOI：
10.1053/j.ajkd.2010.03.026
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Levey AS
中科院分区：
文献类型：
--
作者：
Stevens LA;Schmid CH;Greene T;Zhang YL;Beck GJ;Froissart M;Hamm LL;Lewis JB;Mauer M;Navis GJ;Steffes MW;Eggers PW;Coresh J;Levey AS
MDRD 研究方程在每 1.73 平方米大于 60 毫升/分钟的水平下低估了测量的 GFR，各亚组之间的准确度各不相同；因此，临床实验室未报告估计 GFR (eGFR) ≥ 60 ml/min/1.73 m2。此处，更准确的 GFR 估计方程（CKD-EPI 方程）的性能通过 GFR 水平和临床特征进行报告。诊断准确性测试 来自 16 项研究的 3896 人的汇总数据集，测量了 GFR（不用于开发任一方程）。亚组根据 eGFR、年龄、性别、种族、糖尿病、实体器官移植史和体重指数定义。 eGFR 来自 CKD-EPI 和 MDRD 研究方程和标准化血清肌酐 使用外源性滤过标志物的尿液或血浆清除率测量的 GFR 测量的平均 GFR 为 68 (36) ml/min/1.73 m2。对于小于 30 ml/min/1.73 m2 的 eGFR，两个方程具有相似的偏差（与测量的 GFR 相比的中值差异）。对于 30-59 ml/min/1.73 m2 之间的 eGFR，偏差从 4.9 降低至 2.1 ml/min/1.73 m2（改善 57%）。对于 60-89 ml/min/1.73 m2 之间的 eGFR，偏差从 11.9 降低至 4.2 ml/min/1.73 m2（改善 61%）。对于 90-119 ml/min/1.73 m2 之间的 eGFR，偏差从 10.0 降低至 1.9 ml/min/1.73 m2（改善 75%）。大多数 eGFR < 90 ml/min/1.73 m2 的亚组（BMI 小于 20 kg/m2 除外）的表现相似或有所改善，而 eGFR ≥ 90 ml/min/1.73 m2 的某些亚组的差异更大。测量 GFR 的老年人和少数族裔人数有限。总体而言，在大多数亚组中，CKD-EPI 方程比 MDRD 研究方程更准确。与 MDRD 研究方程相反，可以使用 CKD-EPI 方程报告 eGFR ≥ 60 ml/min/1.73 m2。
The MDRD Study equation underestimates measured GFR at levels greater than 60 ml/min per 1.73 m2, with variable accuracy among subgroups; consequently estimated GFR (eGFR) ≥ 60 ml/min/1.73 m2 is not reported by clinical laboratories. Here, the performance of a more accurate GFR estimating equation, the CKD-EPI equation, is reported by level of GFR and clinical characteristics. Test of diagnostic accuracy Pooled dataset of 3896 people from 16 studies with measured GFR (not used for development of either equation). Subgroups were defined by eGFR, age, sex, race, diabetes, prior solid organ transplant, and body mass index. eGFR from the CKD-EPI and MDRD Study equations and standardized serum creatinine Measured GFR using urinary or plasma clearance of exogenous filtration markers Mean (SD) measured GFR was 68 (36) ml/min/1.73 m2. For eGFR less than 30 ml/min/1.73 m2, both equations have similar bias (median difference compared to measured GFR). For eGFR between 30-59 ml/min/1.73 m2, bias was reduced from 4.9 to 2.1 ml/min/1.73 m2 (57% improvement). For eGFR between 60-89 ml/min/1.73 m2, bias was reduced from 11.9 to 4.2 ml/min/1.73 m2 (61 % improvement). For eGFR between 90-119 ml/min/1.73 m2, bias was reduced from 10.0 to 1.9 ml/min/1.73 m2 (75% improvement). Similar or improved performance was noted for most subgroups with eGFR < 90 ml/min/1.73 m2, other than BMI less than 20 kg/m2, with greater variation noted for some subgroups with eGFR ≥ 90 ml/min/1.73 m2. Limited number of elderly people and racial and ethnic minorities with measured GFR. The CKD-EPI equation is more accurate than the MDRD Study equation overall and across most subgroups. In contrast to the MDRD Study equation, eGFR ≥ 60 ml/min/1.73 m2 can be reported using the CKD-EPI equation.
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影响因子：
8.3
作者：
Kotchen, TA;Piering, AW;Roman, RJ
通讯作者：
Roman, RJ
DOI：
10.1053/j.ajkd.2009.12.016
发表时间：
2010-04
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Matsushita K;Selvin E;Bash LD;Astor BC;Coresh J
通讯作者：
Coresh J
影响因子：
39.2
作者：
Levey AS;Stevens LA;Schmid CH;Zhang YL;Castro AF 3rd;Feldman HI;Kusek JW;Eggers P;Van Lente F;Greene T;Coresh J;CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
通讯作者：
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
影响因子：
19.6
作者：
Hansen, HP;Tauber-Lassen, E;Parving, HH
通讯作者：
Parving, HH
影响因子：
13.6
作者：
Ibrahim, H;Mondress, M;Thomas, W
通讯作者：
Thomas, W