Predicting COVID-19 vaccine take-up: Moving beyond demographics.
Predicting COVID-19 vaccine take-up: Moving beyond demographics.
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DOI：
10.1016/j.bbi.2021.03.021
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Deary IJ
中科院分区：
文献类型：
--
作者：
Batty GD;Deary IJ
随着目前的疫情蔓延，英国现有基于人口的研究--五个出生队列（1946年、1958年、1970年、千禧年、下一步）、英国老龄化纵向研究、雅芳父母和子女纵向研究、苏格兰一代等--的主要研究者们往往在国内资助机构的要求下，争先恐后地进行以COVID-19为导向的调查。再加上大流行前收集的数据，这些数据可以更广泛地量化疾病、隔离和封锁的经济、社会和健康后果（Pierce等人，2020年），尽管如此，在这个庞大的投资组合中投入的资源，而不是更专注于定制项目，是否会有长期价值是有争议的。虽然出现在一本更习惯于心理神经免疫学领域高分辨率研究的期刊上，但伊莱恩·罗伯逊等人在本期发表的论文（罗伯逊等人，2021）的流行和COVID-19疫苗犹豫的预测因素是一个有用的贡献，使用的数据来自嵌套在另一个建立的英国队列，理解社会（伯顿等人，2020年）。群体免疫力是指这样一种概念，即一旦人口中的大多数对传染病产生免疫力，人与人之间传播的可能性就会大大降低，因为那些仍然处于风险中的人由于疾病的低流行率而得到间接保护（Desai和Majumder，2020年）。在这种流行病的背景下，人们争论不休，一种观点认为，这些条件应该通过接种疫苗进行全国封锁来实现，而另一种观点则主张对最脆弱的群体进行分割和保护，其余群体通过社区感染实现群体免疫，恢复更正常的生活（Wise，2020）。选择前者，英国政府以前所未有的速度和规模分发疫苗，这一举措至少接近了他们在其他多种应对措施存在严重缺陷时“击败世界”的目标（Looi，2020）。随着努力继续获得群体免疫力，疫苗犹豫的报告-尽管有安全保证和可用性，但拒绝或延迟接种疫苗（MacDonald，2015）-绝不是目前流行病所独有的（Burger et al.，近几个月来，几种新的有效疫苗的推出，使曾经看似遥远的愿望变成了真实的，这可能有助于许多国家的犹豫明显减少（YouGov，2021）。在牛津大学/阿斯利康刺戳成功测试的宣布后，立即偶然收集了关于理解社会的意向性数据，罗伯逊等人的研究。（Robertson等人，2021）因此提供了疫苗接种何时成为现实的估计。在整个队列中，疫苗犹豫的患病率为18%，但这掩盖了人口亚组之间的明显差异。由于其规模和有目的的抽样，在英国研究中很少（Bécares等人，2020年），理解社会有来自不同种族背景的人的合理代表性。相对于白色英国/爱尔兰研究成员（16%），并非每个少数民族群体都更有可能对疫苗犹豫不决-定义自己为东亚英国人的人的患病率最低（14%）-那些被认为是英国黑人的人（72%）的不情愿程度最高，巴基斯坦/孟加拉国群体是第二大犹豫者（42%）（Robertson et al.，2021年）。对未知的长期副作用的担忧是主要的...
As the present pandemic has unfolded, principal investigators on existing UK population-based studies–the five birth cohorts (1946, 1958, 1970, Millennium, Next Steps), the English Longitudinal Study of Ageing, the Avon Longitudinal Study of Parents and Children, and Generation Scotland, amongst others–often at the behest of domestic funding agencies, have scrambled to conduct COVID-19-orientated surveys. Coupled with data gathered pre-pandemic, these are wellplaced to quantify the economic, social, and health consequences of illness, quarantine, and the lockdown more broadly,(Pierce et al., 2020) although, whether the resources invested across this large portfolio, as opposed to a greater focus on bespoke projects, will have long term value is debatable. While appearing in a journal more accustomed to high-resolution studies in the psychoneuroimmunology field, the paper in this issue by Elaine Robertson and others (Robertson et al., 2021) on the prevalence and predictors of COVID-19 vaccine hesitancy is a useful contribution using data from a study nested within another established UK cohort, Understanding Society (Burton et al., 2020). Herd immunity refers to the notion that, once a stated majority of a population becomes immune to an infectious disease, the probability of between-person spread is substantially diminished because those who remain at risk are indirectly protected owing to the low prevalence of the disease (Desai and Majumder, 2020). Much-debated in the context of this pandemic, one view is that these conditions should be achieved by national lockdown with vaccination, while another advocates for segmentation and protection of the most vulnerable groups with the remainder returning to more normal life with herd immunity realised via community infection (Wise, 2020). Opting for the former, the UK government has distributed vaccines at unprecedented pace and scale in an initiative that at least approaches their aim of being ‘world beating’when multiple other responses have been highly flawed (Looi, 2020). As efforts continue to attain herd immunity, reports of vaccine hesitancy–the refusal or delay in being vaccinated despite safety assurance and availability (MacDonald, 2015)–by no means unique to the present pandemic,(Burger et al., 2021) are concerning, and require rapid quantification and understanding.The unveiling of several new efficacious vaccines in recent months, rendering real what was once a distant-seeming aspiration, may have contributed to the marked secular reduction in hesitancy seen across many countries (YouGov, 2021). With data on intentionality in Understanding Society serendipitously being collected immediately following the announcement of the successful testing of the Oxford University/AstraZeneca jab, the study by Robertson et al.(Robertson et al., 2021) therefore offers estimates when vaccination was a reality. In the full cohort, the prevalence of vaccine hesitancy was 18%, but this conceals stark differences across population sub-groups. Owing to its size and purposeful sampling, rarely amongst UK studies (Bécares et al., 2020), Understanding Society has a reasonable representation of people from diverse ethnic backgrounds. Whereas not every minority group was more likely to be vaccine-hesitant relative to White British/Irish study members (16%)–people defining themselves as East Asian British had the lowest prevalence (14%)–those identifying as Black British (72%) had the highest levels of reluctance, with Pakistani/Bangladeshi groups being the next most hesitant (42%)(Robertson et al., 2021). Concern about the unknown longer term side-effects was the primary …
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影响因子：
7.8
作者：
Wang J;Jing R;Lai X;Zhang H;Lyu Y;Knoll MD;Fang H
通讯作者：
Fang H
影响因子：
15.1
作者：
Lassale, Camille;Gaye, Bamba;Batty, G. David
通讯作者：
Batty, G. David
影响因子：
3
作者：
Deary, Ian J.;Gale, Catharine R.;Price, Jacqueline F.
通讯作者：
Price, Jacqueline F.
影响因子：
6.3
作者：
Gale CR;Deary IJ;Wardle J;Zaninotto P;Batty GD
通讯作者：
Batty GD
DOI：
10.15585/mmwr.mm7006e3
发表时间：
2021-02-12
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Nguyen KH;Srivastav A;Razzaghi H;Williams W;Lindley MC;Jorgensen C;Abad N;Singleton JA
通讯作者：
Singleton JA