An assessment of the impact of incorporating time-of-flight information into clinical PET/CT imaging.
An assessment of the impact of incorporating time-of-flight information into clinical PET/CT imaging.
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DOI：
10.2967/jnumed.109.068098
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Townsend DW
中科院分区：
文献类型：
--
作者：
Lois C;Jakoby BW;Long MJ;Hubner KF;Barker DW;Casey ME;Conti M;Panin VY;Kadrmas DJ;Townsend DW
对511keV光子具有良好阻挡能力的快闪烁体的引入，重新引起了人们对飞行时间正电子发射断层扫描(TOF-PET)的兴趣。测量来自正电子湮没的一对光子到达时间之间的差异的能力提高了图像的信噪比(SNR)。改进的程度取决于正电子活动的范围和分布以及PET扫描仪的时间分辨率。虽然可以对体模成像做出具体的估计，但在临床情况下，TOF-PET的影响更难量化。本文介绍的结果量化了TOF在具有挑战性的模体实验中的益处，然后定性和定量地评估了将TOF信息纳入临床研究重建的影响。在这项涉及100名肿瘤患者的研究中，患者体重指数(BMI)和信噪比增益之间存在明显的相关性，TOF的增益在1.2到2之间，这与TOF-PET扫描仪590 ps的时间分辨率一致。两位核医学医生对TOF和非TOF图像进行的视觉比较证实了将TOF纳入重建的优势，包括更好地清晰度小病变和图像细节、改善一致性和降低噪音。
The introduction of fast scintillators with good stopping power for 511 keV photons has renewed interest in Time-of-Flight Positron Emission Tomography (TOF-PET). The ability to measure the difference between the arrival times of a pair of photons originating from positron annihilation improves the image signal-to-noise ratio (SNR). The level of improvement depends upon the extent and distribution of the positron activity and the time resolution of the PET scanner. While specific estimates can be made for phantom imaging, the impact of TOF-PET is more difficult to quantify in clinical situations. The results presented here quantify the benefit of TOF in a challenging phantom experiment and then assesses both qualitatively and quantitatively the impact of incorporating TOF information into the reconstruction of clinical studies. A clear correlation between patient body mass index (BMI) and gain in SNR was observed in this study involving 100 oncology patient studies, with a gain due to TOF ranging from 1.2 to 2, which is consistent with the 590 ps time resolution of the TOF-PET scanner. The visual comparison of TOF and non-TOF images performed by two nuclear medicine physicians confirmed the advantages of incorporating TOF into the reconstruction, advantages that include better definition of small lesions and image details, improved uniformity, and noise reduction.
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DOI：
10.2967/jnumed.109.063016
发表时间：
2009-08
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Kadrmas DJ;Casey ME;Conti M;Jakoby BW;Lois C;Townsend DW
通讯作者：
Townsend DW
影响因子：
1.8
作者：
Jakoby, Bjoern W.;Bercier, Yanic;Townsend, David W.
通讯作者：
Townsend, David W.
影响因子：
1.8
作者：
MELCHER, CL;SCHWEITZER, JS
通讯作者：
SCHWEITZER, JS
影响因子：
1.8
作者：
Watson, Charles C.
通讯作者：
Watson, Charles C.
影响因子：
3.5
作者：
Conti, M;Bendriem, B;Panin, V
通讯作者：
Panin, V