Effect of Exercise on Brain Health: The Potential Role of Lactate as a Myokine.
Effect of Exercise on Brain Health: The Potential Role of Lactate as a Myokine.
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DOI：
10.3390/metabo11120813
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发表时间：
2021-11-29
期刊：
影响因子：
4.1
通讯作者：
Ogoh S
中科院分区：
文献类型：
--
作者：
Hashimoto T;Tsukamoto H;Ando S;Ogoh S
在流行病学研究和随机对照试验中，习惯性运动有益于大脑健康，如认知和心理健康。一般来说，可以合理地说，急性运动的生理益处可以预防晚年的大脑疾病，如果这种运动是习惯性/长期进行的。然而，通过慢性运动改善脑功能的机制仍然不完全清楚，因为这种机制被认为是多因素的，如适应反复急性运动。本文认为脑代谢可能是决定脑功能的重要生理因素。在代谢物中，提供乳酸以满足升高的神经活动并调节脑血管系统和氧化还原状态以响应运动可能是运动增强大脑健康的原因。在这里，我们总结了目前的知识，运动对大脑健康的影响，特别是认知能力，通过乳酸的潜在机制。关于慢性运动对脑功能的影响，运动强度和方式的相关性，特别是高强度间歇运动，被认为诱导“代谢性肌因子”（即，乳酸盐）对大脑健康的作用。
It has been well established in epidemiological studies and randomized controlled trials that habitual exercise is beneficial for brain health, such as cognition and mental health. Generally, it may be reasonable to say that the physiological benefits of acute exercise can prevent brain disorders in late life if such exercise is habitually/chronically conducted. However, the mechanisms of improvement in brain function via chronic exercise remain incompletely understood because such mechanisms are assumed to be multifactorial, such as the adaptation of repeated acute exercise. This review postulates that cerebral metabolism may be an important physiological factor that determines brain function. Among metabolites, the provision of lactate to meet elevated neural activity and regulate the cerebrovascular system and redox states in response to exercise may be responsible for exercise-enhanced brain health. Here, we summarize the current knowledge regarding the influence of exercise on brain health, particularly cognitive performance, with the underlying mechanisms by means of lactate. Regarding the influence of chronic exercise on brain function, the relevance of exercise intensity and modality, particularly high-intensity interval exercise, is acknowledged to induce “metabolic myokine” (i.e., lactate) for brain health.
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DOI：
10.4103/1793-5482.145375
发表时间：
2016-04
期刊：
Asian journal of neurosurgery
影响因子：
--
作者：
Bisri T;Utomo BA;Fuadi I
通讯作者：
Fuadi I
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
在健康的年轻人中，低强度耐药性运动后，低强度耐药性运动后，认知抑制性控制的同样改善：一项初步研究。
影响因子：
2.3
作者：
Dora, Kento;Suga, Tadashi;Tomoo, Keigo;Sugimoto, Takeshi;Mok, Ernest;Tsukamoto, Hayato;Takada, Shingo;Hashimoto, Takeshi;Isaka, Tadao
通讯作者：
Isaka, Tadao
影响因子：
4
作者：
Dora K;Suga T;Tomoo K;Sugimoto T;Mok E;Tsukamoto H;Takada S;Hashimoto T;Isaka T
通讯作者：
Isaka T
影响因子：
64.8
作者：
Gordon GR;Choi HB;Rungta RL;Ellis-Davies GC;MacVicar BA
通讯作者：
MacVicar BA