Characterization of the effects of oxytocin on fear recognition in patients with schizophrenia and in healthy controls.
Characterization of the effects of oxytocin on fear recognition in patients with schizophrenia and in healthy controls.
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DOI：
10.3389/fnins.2013.00127
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发表时间：
2013
影响因子：
4.3
通讯作者：
Levkovitz Y
中科院分区：
文献类型：
--
作者：
Fischer-Shofty M;Shamay-Tsoory SG;Levkovitz Y
患有精神分裂症的人通常在识别情感面部表情方面表现出明显的缺陷，这是更广泛的社会认知障碍的一部分。研究表明，对负面情绪的识别，特别是恐惧识别，在精神分裂症患者中尤其受损。最近，我们报道了鼻内给药OT（IN OT）增加了一组健康男性正确识别恐惧的能力。本研究的目的是检查INOT管理对精神分裂症患者的恐惧识别的影响。基于以前的研究，我们还试图研究OT依赖于基线性能的可能的选择性影响，假设IN OT对不太熟练的个体有更大的增强作用。因此，假设与对照相比，患者在施用INOT后将显示出更多的恐惧识别改善。66名受试者（31名精神分裂症患者，35名健康对照）参加了本研究。所有受试者均接受单剂量24 IU IN OT和等量安慰剂治疗，间隔1周。参与者准确识别恐惧和快乐的能力是通过面部变形任务来评估的。总的来说，作为一个群体，患者和健康对照参与者在识别恐惧的面部表情方面更准确，但在INOT给药后，与安慰剂给药后的表现相比，他们并不快乐。在患者和健康对照组中，IN OT对情绪识别的影响没有差异。然而，研究结果表明，IN OT具有选择性效应，即激素仅在基线表现低于中位数的个体中改善恐惧识别，而不管他们的精神状态如何。
Individuals who suffer from schizophrenia often show a marked deficit in recognition of emotional facial expressions, as part of broader impairment of social cognition. Research has shown that recognition of negative emotions, specifically fear recognition, is particularly impaired among patients with schizophrenia. Recently we reported that intranasal administration of OT (IN OT) increased the ability to correctly recognize fear in a group of healthy men. The aim of the current study was to examine the effects of IN OT administration on fear recognition among patients with schizophrenia. Based on previous research, we also sought to examine a possible selective effect of OT dependent on baseline performance, hypothesizing that IN OT would have a greater enhancement effect on less proficient individuals. It was thus hypothesized that patients will show more improvement in fear recognition following the administration of IN OT as compared to controls. Sixty six participants (31 schizophrenia patients, 35 healthy controls) were enrolled in the current study. All participants received treatment of a single dose of 24 IU IN OT and an equivalent amount of placebo, 1 week apart. The participants' ability to accurately recognize fear and happiness was evaluated using a face morphing task. Overall, as a group, both patients and healthy control participants were more accurate in recognizing fearful facial expressions, but not happy faces, following IN OT administration, as compared to their performance following placebo. IN OT did not differentially affect emotion recognition in patients and healthy controls. Yet, the results indicated a selective effect for IN OT, in which the hormone improves fear recognition only among individuals whose baseline performance was below the median, regardless of their psychiatric status.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
8.2
作者：
Bartz JA;Zaki J;Bolger N;Hollander E;Ludwig NN;Kolevzon A;Ochsner KN
通讯作者：
Ochsner KN
DOI：
10.3758/bf03203630
发表时间：
1996-02-01
期刊：
BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS
影响因子：
--
作者：
Erdfelder, E;Faul, F;Buchner, A
通讯作者：
Buchner, A
影响因子：
6.9
作者：
Fertuck EA;Jekal A;Song I;Wyman B;Morris MC;Wilson ST;Brodsky BS;Stanley B
通讯作者：
Stanley B
影响因子：
4.5
作者：
Edwards, Jane;Pattison, Philippa E.;Wales, Roger J.
通讯作者：
Wales, Roger J.