Alphavirus Nucleocapsid Packaging and Assembly.
Alphavirus Nucleocapsid Packaging and Assembly.
复制标题
甲病毒核衣壳包装和组装。
DOI：
10.3390/v10030138
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发表时间：
2018-03-20
期刊：
影响因子：
--
通讯作者：
Kuhn RJ
中科院分区：
文献类型：
--
作者：
Mendes A;Kuhn RJ
甲病毒核衣壳在感染细胞的细胞质中由240个拷贝的衣壳蛋白和约11 kb正链基因组RNA组装而成。然而，衣壳如何特异性地选择其RNA包装并围绕其组装的挑战仍然是一个难以解决的问题。在这篇综述中，我们将总结什么是已知的甲病毒衣壳蛋白，包装信号，以及它们在包装和组装机制中的作用。我们将回顾包装信号的发现，以及如何有尽可能多的证据支持，以及反对，其要求指定包装的基因组RNA。最后，我们将比较这个模型与其他病毒系统，包括特别提到一个相对较新的想法，RNA包装的基础上存在的多个最小包装信号的整个基因组称为两个阶段的机制。这篇综述将为进一步研究RNA病毒如何能够从相对混乱的细胞质中选择自己的货物的基本方式提供基础。
Alphavirus nucleocapsids are assembled in the cytoplasm of infected cells from 240 copies of the capsid protein and the approximately 11 kb positive strand genomic RNA. However, the challenge of how the capsid specifically selects its RNA package and assembles around it has remained an elusive one to solve. In this review, we will summarize what is known about the alphavirus capsid protein, the packaging signal, and their roles in the mechanism of packaging and assembly. We will review the discovery of the packaging signal and how there is as much evidence for, as well as against, its requirement to specify packaging of the genomic RNA. Finally, we will compare this model with those of other viral systems including particular reference to a relatively new idea of RNA packaging based on the presence of multiple minimal packaging signals throughout the genome known as the two stage mechanism. This review will provide a basis for further investigating the fundamental ways of how RNA viruses are able to select their own cargo from the relative chaos that is the cytoplasm.
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影响因子：
3.7
作者：
Ferreira, D;Hernandez, R;Brown, DT
通讯作者：
Brown, DT
影响因子：
4.8
作者：
Firth AE;Chung BY;Fleeton MN;Atkins JF
通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
MacDonald, Margaret R.
DOI：
10.1073/pnas.77.11.6376
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
GAROFF, H;FRISCHAUF, AM;DELIUS, H
通讯作者：
DELIUS, H
影响因子：
5.4
作者：
Garmashova, Natalia;Atasheva, Svetlana;Frolov, Ilya
通讯作者：
Frolov, Ilya