The Effects of Workplace-Based HIV Self-testing on Uptake of Testing and Linkage to HIV Care or Prevention by Men in Uganda (WISe-Men): Protocol for a Cluster Randomized Trial.
The Effects of Workplace-Based HIV Self-testing on Uptake of Testing and Linkage to HIV Care or Prevention by Men in Uganda (WISe-Men): Protocol for a Cluster Randomized Trial.
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DOI：
10.2196/25099
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发表时间：
2021-11-01
影响因子：
1.7
通讯作者：
Sewankambo NK
中科院分区：
文献类型：
--
作者：
Muwanguzi PA;Ngabirano TD;Kiwanuka N;Nelson LE;Nasuuna EM;Osingada CP;Nabunya R;Nakanjako D;Sewankambo NK
在撒哈拉以南非洲，男子接受艾滋病毒检测的比例仍然很低。在工作场所进行艾滋病毒自我检测是一种新的方法，可以增加男性获得检测的机会。然而，测试后服务的获取和连接仍然是一个挑战。本协议的目的是描述一个集群随机试验（CRT）-工作场所为基础的艾滋病毒自我检测男性（WISe-Men）-评估艾滋病毒自我检测在工作场所对艾滋病毒检测服务（HTS）的吸收和联系的影响，在乌干达的私人保安服务中雇用的男性之间的治疗和预防服务。这是一个双臂CRT，涉及在乌干达两个地区受雇于私营保安服务的男子。干预组的参与者将使用OraQuick测试包进行基于工作场所的HIVST。控制组的人员将在其工作场所接受常规HTS。除了HTS，干预组和对照组的参与者还将接受其他测试和评估，包括血压评估、血糖和BMI测量以及梅毒快速诊断测试。主要成果是接受艾滋病毒检测。次要结果包括艾滋病毒状况报告、与艾滋病毒护理的联系以及艾滋病毒检测后的确证性检测、在确证性艾滋病毒检测后开始抗逆转录病毒治疗、接受自愿医疗男性包皮环切术、坚持使用避孕套以及高危人群接受暴露前预防。参与者招募于2020年2月开始，试验仍在招募研究参与者。目前正在对入组的受试者进行随访。数据收集及分析预计于二零二一年十二月完成。WISe-Men试验将提供有关在工作场所进行自我检测是否会增加艾滋病毒检测的信息，以及在乌干达男性占主导地位的工作场所与护理和预防服务的联系。此外，研究结果将帮助我们提出改善男性参与HTS的策略，以及在反应性或非反应性HIVST结果后改善与进一步护理联系的方法。ClinicalTrials.gov NCT 04164433; https://clinicaltrials.gov/ct2/show/NCT04164433 DERR 1 -10.2196/25099
HIV testing uptake remains low among men in sub-Saharan Africa. HIV self-testing (HIVST) at the workplace is a novel approach to increase the availability of, and access to, testing among men. However, both access and linkage to posttest services remain a challenge. The aim of this protocol is to describe a cluster randomized trial (CRT)—Workplace-Based HIV Self-testing Among Men (WISe-Men)—to evaluate the effect of HIVST in workplace settings on the uptake of HIV testing services (HTS) and linkage to treatment and prevention services among men employed in private security services in Uganda. This is a two-arm CRT involving men employed in private security services in two Ugandan districts. The participants in the intervention clusters will undergo workplace-based HIVST using OraQuick test kits. Those in the control clusters will receive routine HTS at their work premises. In addition to HTS, participants in both the intervention and control arms will undergo other tests and assessments, which include blood pressure assessment, blood glucose and BMI measurement, and rapid diagnostic testing for syphilis. The primary outcome is the uptake of HIV testing. The secondary outcomes include HIV status reporting, linkage into HIV care and confirmatory testing following HIVST, initiation of antiretroviral therapy following a confirmatory HIV test, the uptake of voluntary medical male circumcision, consistent condom use, and the uptake of pre-exposure prophylaxis by the most at-risk populations. Participant enrollment commenced in February 2020, and the trial is still recruiting study participants. Follow-up for currently enrolled participants is ongoing. Data collection and analysis is expected to be completed in December 2021. The WISe-Men trial will provide information regarding whether self-testing at worksites increases the uptake of HIV testing as well as the linkage to care and prevention services at male-dominated workplaces in Uganda. Additionally, the findings will help us propose strategies for improving men’s engagement in HTS and ways to improve linkage to further care following a reactive or nonreactive HIVST result. ClinicalTrials.gov NCT04164433; https://clinicaltrials.gov/ct2/show/NCT04164433 DERR1-10.2196/25099
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影响因子：
11.8
作者：
Eaton, Jeffrey W.;Johnson, Cheryl C.;Gregson, Simon
通讯作者：
Gregson, Simon
影响因子：
3.4
作者：
Byamugisha R;Tumwine JK;Semiyaga N;Tylleskär T
通讯作者：
Tylleskär T
DOI：
10.4172/2155-6113.1000725
发表时间：
2017-01-01
期刊：
Journal of AIDS and Clinical Research
影响因子：
--
作者：
Jennings, L.;Conserve, D. F.;Maman, S. L. S.
通讯作者：
Maman, S. L. S.
影响因子：
3
作者：
Müller A
通讯作者：
Müller A
影响因子：
105.7
作者：
Campbell, Marion K.;Piaggio, Gilda;Altman, Douglas G.
通讯作者：
Altman, Douglas G.