Follicular helper T cells in immunity and systemic autoimmunity.
Follicular helper T cells in immunity and systemic autoimmunity.
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DOI：
10.1038/nrrheum.2012.58
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发表时间：
2012-05-01
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--
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滤泡辅助性T（TFH）细胞是胸腺依赖性抗原免疫后B细胞成熟和免疫球蛋白产生所必需的。然而，TFH细胞的发育和功能不如经典的CD 4+效应T细胞亚群，包括T辅助细胞-1（TH 1）、TH 2和TH 17细胞清楚。因此，我们对人类TFH细胞的起源及其在自身免疫发展中的作用的理解仍然不完整。然而，来自系统性红斑狼疮（SLE）动物模型和系统性自身免疫性疾病患者的证据表明，这些细胞对于致病性自身抗体的产生是必需的，其方式类似于它们在正常免疫应答期间促进B细胞成熟的作用。在这篇综述中，我讨论了这些发现，增加了我们对TFH细胞在正常和异常免疫反应中的发育和功能的认识。这些信息可能会提高我们对自身免疫性疾病（如SLE）的理解，并强调TFH细胞作为这些疾病治疗靶点的潜力。
Follicular helper T (TFH) cells are essential for B-cell maturation and immunoglobulin production after immunization with thymus-dependent antigens. Nevertheless, the development and function of TFH cells have been less clearly defined than classic CD4+ effector T-cell subsets, including T-helper-1 (TH1), TH2 and TH17 cells. As such, our understanding of the genesis of TFH cells in humans and their role in the development of autoimmunity remains incomplete. However, evidence from animal models of systemic lupus erythematosus (SLE) and patients with systemic autoimmune diseases suggests that these cells are necessary for pathogenic autoantibody production, in a manner analogous to their role in promotion of B-cell maturation during normal immune responses. In this Review, I discuss the findings that have increased our knowledge of TFH-cell development and function in normal and aberrant immune responses. Such information might improve our understanding of autoimmune diseases, such as SLE, and highlights the potential of TFH cells as therapeutic targets in these diseases.
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