Controlling the Actuation Rate of Low-Density Shape-Memory Polymer Foams in Water.
Controlling the Actuation Rate of Low-Density Shape-Memory Polymer Foams in Water.
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DOI：
10.1002/macp.201200342
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发表时间：
2013-06-13
影响因子：
2.5
通讯作者：
Wilson, Thomas S.
中科院分区：
文献类型：
--
作者：
Singhal, Pooja;Boyle, Anthony;Brooks, Marilyn L.;Infanger, Stephen;Letts, Steve;Small, Ward;Maitland, Duncan J.;Wilson, Thomas S.
SMP已被证明在水分存在下由于塑化而在低于其干燥玻璃化转变温度下致动。这种行为已被提出作为自驱动机制的SMP在水/生理介质。然而，对SMP致动速率的控制（体内经导管装置递送应用的关键因素）先前尚未报道。在此，描述了一系列具有系统变化的疏水性的聚氨酯SMP，其允许将其在水中完全形状恢复的时间控制在2分钟以下至24小时以上。这种对SMP致动速率的控制可以潜在地提供在致动之前可能将它们暴露于高湿度环境的条件下它们的递送的显著改善。
SMPs have been shown to actuate below their dry glass transition temperatures in the presence of moisture due to plasticization. This behavior has been proposed as a self-actuating mechanism of SMPs in water/physiological media. However, control over the SMP actuation rate, a critical factor for in vivo transcatheter device delivery applications, has not been previously reported. Here, a series of polyurethane SMPs with systematically varied hydrophobicity is described that permits control of the time for their complete shape recovery in water from under 2 min to more than 24 h. This control over the SMP actuation rate can potentially provide significant improvement in their delivery under conditions, which may expose them to high-moisture environments prior to actuation.
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影响因子：
4.1
作者：
Di Prima, M. A.;Lesniewski, M.;Campbell, D.
通讯作者：
Campbell, D.
影响因子：
9.7
作者：
De Nardo, Luigi;Alberti, Rachele;Fare, Silvia
通讯作者：
Fare, Silvia
影响因子：
4.6
作者：
Small, Ward;Buckley, Patrick R.;Maitland, Duncan J.
通讯作者：
Maitland, Duncan J.
影响因子：
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作者：
Metcalfe, A;Desfaits, AC;Raymond, J
通讯作者：
Raymond, J
DOI：
10.1016/s0020-7403(00)00043-6
发表时间：
2001-03-01
影响因子：
7.3
作者：
Andrews, EW;Gioux, G;Gibson, LJ
通讯作者：
Gibson, LJ