The genetics of child psychiatric disorders: focus on autism and Tourette syndrome.
The genetics of child psychiatric disorders: focus on autism and Tourette syndrome.
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DOI：
10.1016/j.neuron.2010.10.004
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发表时间：
2010-10-21
期刊：
影响因子：
16.2
通讯作者：
State, Matthew W.
中科院分区：
文献类型：
--
作者：
State, Matthew W.
对儿童精神疾病遗传学的研究已经开始揭示精神病理学的分子和细胞机制。第一批成功的菌株是对常见神经精神疾病的等位基因结构的日益复杂的理解的结果;大型患者队列的整合;基因组工具的出现使得能够对罕见和常见的遗传变异进行全面研究;以及发育神经科学的进步推动了遗传发现的快速转化。这些问题，以及现在面临的机遇和挑战，基因发现的努力在遗传复杂的条件下，解决两个典型的儿童疾病：自闭症和抽动秽语综合征。
Investigations into the genetics of child psychiatric disorders have begun to shed light on molecular and cellular mechanisms of psychopathology. The first strains of success are the result of an increasingly sophisticated appreciation of the allelic architecture of common neuropsychiatric disorders; the consolidation of large patient cohorts; the emergence of genomic tools enabling comprehensive studies of rare as well as common genetic variation; and advances in developmental neuroscience that are fueling the rapid translation of genetic findings. These issues, as well as the opportunities and challenges that now confront gene discovery efforts in genetically complex conditions, are addressed with regard to two paradigmatic childhood disorders: autism and Tourette syndrome.
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