Facile fabrication of high performances MTX nanocomposites with natural biomembrane bacterial nanoparticles using GP
Facile fabrication of high performances MTX nanocomposites with natural biomembrane bacterial nanoparticles using GP
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使用 GP 轻松制造具有天然生物膜细菌纳米颗粒的高性能 MTX 纳米复合材料
DOI：
10.1016/j.matlet.2013.03.052
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发表时间：
2013-06
影响因子：
3
通讯作者：
Deng, Qiongjia
中科院分区：
文献类型：
--
作者：
Liu, Yuangang;Xie, Maobin;Wang, Shibin;Zheng, Qiyao;Chen, Aizheng;Deng, Qiongjia
利用磁性细菌AMB-1的磁小体（bacterial magnetosomes，BM），以天然脂质双膜包裹磁性氧化铁，构建了一种新型的磁靶向抗肿瘤给药系统。使用京尼平（GP）将甲氨蝶呤（MTX）负载在BM膜上。平均粒径为44.4±1.5nm，载药量为43.3-49.6%，包封率为76.5-98%，缓释效果好，释放时间可达2个月以上。结果表明，该载体具有良好的缓释性能，在药物释放方面具有很大的应用潜力。
A novel magnetic targeting anti-tumor drug delivery system was constructed with bacterial magnetosomes (BMs) from Magnetospirillum magneticum AMB-1, which have natural magnetic iron oxide and enveloped by natural lipid bi-membrane. Methotrexate (MTX) was loaded on the BMs membrane using genipin (GP). The average particle size was 44.4±1.5nm and this system showed high drug loading (43.3–49.6%), high encapsulation efficiency (76.5–98%), and long-term release behaviors (over two months) without initial burst release to low molecule drug MTX. The method was simple but very efficient, and the results indicated that the new carrier exhibited a great potential for application in drug delivery with excellent performances for long-term release.
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影响因子：
13.3
作者：
Kohler, N;Sun, C;Zhang, MQ
通讯作者：
Zhang, MQ
影响因子：
4.4
作者：
de Oliveira, Alice Rodrigues;Molina, Eduardo Ferreira;da Silva-Junior, Arnobio Antonio
通讯作者：
da Silva-Junior, Arnobio Antonio
DOI：
10.1002/(sici)1097-4636(19990915)46:4
发表时间：
1999-09
期刊：
Journal of biomedical materials research
影响因子：
--
作者：
M. Yağmurlu;F. Korkusuz;I. Gursel;P. Korkusuz;Ülken Örs;V. Hasırcı;V. Hasırcı
通讯作者：
M. Yağmurlu;F. Korkusuz;I. Gursel;P. Korkusuz;Ülken Örs;V. Hasırcı;V. Hasırcı
DOI：
10.1016/j.ejpb.2010.06.014
发表时间：
2010-10-01
影响因子：
4.9
作者：
Singka, Gillian S. Leslie;Abu Samah, Nor;Heard, Charles M.
通讯作者：
Heard, Charles M.
影响因子：
5.1
作者：
Delia Soto‐Castro;Jorge A. Cruz-Morales;M. T. Ramírez Apán;Patricia Guadarrama
通讯作者：
Delia Soto‐Castro;Jorge A. Cruz-Morales;M. T. Ramírez Apán;Patricia Guadarrama