A cerebellum-like circuit in the auditory system cancels responses to self-generated sounds.
A cerebellum-like circuit in the auditory system cancels responses to self-generated sounds.
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DOI：
10.1038/nn.4567
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发表时间：
2017-07
影响因子：
25
通讯作者：
Sawtell NB
中科院分区：
文献类型：
--
作者：
Singla S;Dempsey C;Warren R;Enikolopov AG;Sawtell NB
耳蜗背核（DCN）整合了听觉神经输入与各种感觉和运动信号的处理内类似于小脑回路。然而，DCN如何促进早期听觉处理一直是一个长期存在的难题。在小鼠舔行为过程中使用电生理记录，我们发现DCN神经元在很大程度上不受自发声音的影响，同时对外部声刺激保持敏感。对被催眠的老鼠的录音，以及对神经活动的操纵，表明自发的声音被苔藓纤维传递的非听觉信号所抵消。此外，DCN神经元表现出逐渐减少，他们的声音刺激的时间与舔的反应。总之，这些发现表明，DCN可以作为一个自适应滤波器，用于消除自生的声音。自适应滤波以前已经建立了小脑样的感觉结构在鱼类，这表明在脊椎动物的保守功能，这样的结构。
The dorsal cochlear nucleus (DCN) integrates auditory nerve input with a diverse array of sensory and motor signals processed within circuity similar to the cerebellum. Yet how the DCN contributes to early auditory processing has been a longstanding puzzle. Using electrophysiological recordings in mice during licking behavior we show that DCN neurons are largely unaffected by self-generated sounds while remaining sensitive to external acoustic stimuli. Recordings in deafened mice, together with neural activity manipulations, indicate that self-generated sounds are cancelled by non-auditory signals conveyed by mossy fibers. In addition, DCN neurons exhibit gradual reductions in their responses to acoustic stimuli that are temporally correlated with licking. Together, these findings suggest that DCN may act as an adaptive filter for cancelling self-generated sounds. Adaptive filtering has been established previously for cerebellum-like sensory structures in fish suggesting a conserved function for such structures across vertebrates.
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