Feeling safe in the plane: neural mechanisms underlying superior action control in airplane pilot trainees--a combined EEG/MRS study.
Feeling safe in the plane: neural mechanisms underlying superior action control in airplane pilot trainees--a combined EEG/MRS study.
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DOI：
10.1002/hbm.22530
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发表时间：
2014-10
影响因子：
4.8
通讯作者：
Beste, Christian
中科院分区：
文献类型：
--
作者：
Yildiz, Ali;Quetscher, Clara;Dharmadhikari, Shalmali;Chmielewski, Witold;Glaubitz, Benjamin;Schmidt-Wilcke, Tobias;Edden, Richard;Dydak, Ulrike;Beste, Christian
在日常生活中，我们需要应用策略来串联不同的行为，以有效地展开行为。虽然动作级联反应的缺陷被广泛研究，但几乎对调节高于正常水平的优越表现的神经机制知之甚少。为了研究这个问题，我们调查了飞机飞行员实习生的动作控制。我们使用一种止变范式，该范式能够基于数学约束来估计行动级联的效率。行为和脑电数据根据这些限制进行分析，并与使用磁共振波谱(MRS)从纹状体伽马氨基丁酸(GABA)-ERIC系统获得的神经化学数据相结合。我们的研究表明，通过强化注意过程，绕过反应选择过程，可以驱动高水平的动作级联反应，就像飞机飞行员训练生一样。结果表明，纹状体GABA和谷氨酸+谷氨酰胺的浓度对动作效率、反应速度和注意门控功能均有调节作用。与动作表现正常的受试者相比，在动作表现优异的级联反应中，GABA和谷氨酸+谷氨酰胺浓度的类似增加会导致更强的神经生理和行为效应。
In day-to-day life, we need to apply strategies to cascade different actions for efficient unfolding of behaviour. While deficits in action cascading are examined extensively, almost nothing is known about the neuronal mechanisms mediating superior performance above the normal level. To examine this question, we investigate action control in airplane pilot trainees. We use a stop-change paradigm that is able to estimate the efficiency of action cascading on the basis of mathematical constraints. Behavioural and EEG data is analyzed along these constraints and integrated with neurochemical data obtained using Magnetic Resonance Spectroscopy (MRS) from the striatal gamma-aminobutyric acid (GABA) -ergic system. We show that high performance in action cascading, as exemplified in airplane pilot trainees, can be driven by intensified attentional processes, circumventing response selection processes. The results indicate that the efficiency of action cascading and hence the speed of responding as well as attentional gating functions are modulated by striatal GABA and Glutamate + Glutamine concentrations. In superior performance in action cascading similar increases in the concentrations of GABA and Glutamate + Glutamine lead to stronger neurophysiological and behavioural effects as compared to subjects with normal performance in action cascading.
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影响因子：
3.1
作者：
Beste, Christian;Stock, Ann-Kathrin;Saft, Carsten
通讯作者：
Saft, Carsten
影响因子：
3.7
作者：
Mueckschel, Moritz;Stock, Ann-Kathrin;Beste, Christian
通讯作者：
Beste, Christian
影响因子：
2.6
作者：
Brisson, Benoit;Jolicaeur, Pierre
通讯作者：
Jolicaeur, Pierre
影响因子：
1.3
作者：
Verleger, R;Jaskowski, P;Wascher, E
通讯作者：
Wascher, E
影响因子：
16.2
作者：
Duncan J
通讯作者：
Duncan J