Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism.
Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism.
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DOI：
10.1007/s11689-009-9009-8
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发表时间：
2009-03
影响因子：
4.9
通讯作者：
Piven, Joseph
中科院分区：
文献类型：
--
作者：
Hazlett, Heather Cody;Poe, Michele D.;Lightbody, Amy A.;Gerig, Guido;MacFall, James R.;Ross, Allison K.;Provenzale, James;Martin, Arianna;Reiss, Allan L.;Piven, Joseph
检查与FXS儿童的行为特征相关的亚结构中的脑体积，与特发性自闭症儿童和对照儿童进行比较。在第一时间点进行脑亚结构的横断面研究，作为正在进行的FXS脑发育纵向MRI研究的一部分。该研究包括52名年龄在18-42个月之间的FXS男孩和118名对照儿童（自闭症-非FXS，发育迟缓和典型发育的男孩）。患有FXS和自闭症的儿童具有显著增大的尾状核体积和较小的杏仁核体积;而那些患有自闭症但没有FXS的儿童（即，特发性孤独症）的尾状核体积只有适度的增大，但杏仁核体积的增大更为强烈。虽然我们在选定的脑容量中观察到这种双重分离，但在这些组之间没有观察到自闭症行为严重程度的显著差异。这项研究提供了一个独特的检查早期大脑发育的两种疾病，FXS和特发性自闭症，重叠的行为特征，但两种不同的模式的大脑形态。我们观察到，尽管我们的FXS样本中有近三分之一符合自闭症的标准，但患有FXS和自闭症的儿童的脑容量差异与患有特发性自闭症的儿童不同。这些发现强调了在自闭症行为研究中解决异质性的重要性。
To examine brain volumes in substructures associated with the behavioral features of children with FXS compared to children with idiopathic autism and controls. A cross-sectional study of brain substructures was conducted at the first time-point as part of an ongoing longitudinal MRI study of brain development in FXS. The study included 52 boys between 18–42 months of age with FXS and 118 comparison children (boys with autism-non FXS, developmental-delay, and typical development). Children with FXS and autistic disorder had substantially enlarged caudate volume and smaller amygdala volume; whereas those children with autistic disorder without FXS (i.e., idiopathic autism) had only modest enlargement in their caudate nucleus volumes but more robust enlargement of their amygdala volumes. Although we observed this double dissociation among selected brain volumes, no significant differences in severity of autistic behavior between these groups were observed. This study offers a unique examination of early brain development in two disorders, FXS and idiopathic autism, with overlapping behavioral features, but two distinct patterns of brain morphology. We observed that despite almost a third of our FXS sample meeting criteria for autism, the profile of brain volume differences for children with FXS and autism differed from those with idiopathic autism. These findings underscore the importance of addressing heterogeneity in studies of autistic behavior.
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影响因子：
6.9
作者：
BAILEY, A;LECOUTEUR, A;RUTTER, M
通讯作者：
RUTTER, M
影响因子：
--
作者：
Gueorguieva, R;Krystal, JH
通讯作者：
Krystal, JH
影响因子：
9.9
作者：
Aylward, EH;Minshew, NJ;Singh, N
通讯作者：
Singh, N
DOI：
10.1002/ajmg.b.30241
发表时间：
2005-11-05
影响因子：
2.8
作者：
Hessl, D;Tassone, F;Hagerman, RJ
通讯作者：
Hagerman, RJ
影响因子：
2.5
作者：
Antar, LN;Dictenberg, JB;Basselll, GJ
通讯作者：
Basselll, GJ