Angiopoietin-2 in experimental colitis.
Angiopoietin-2 in experimental colitis.
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DOI：
10.1002/ibd.21150
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发表时间：
2010-06
影响因子：
4.9
通讯作者：
Alexander, J. Steven
中科院分区：
文献类型：
--
作者：
Ganta, Vijay C.;Cromer, Walter;Mills, Ginny L.;Traylor, James;Jennings, Merilyn;Daley, Sarah;Clark, Benjamin;Mathis, J. Michael;Bernas, Michael;Boktor, Moheb;Jordan, Paul;Witte, Marlys;Alexander, J. Steven
炎症性肠病（IBD）的病理生理学包括白细胞浸润、血液和淋巴重塑、体重减轻和蛋白质肠病。血管生成素-2（Ang-2）在肠道炎症、白细胞浸润和血管生成中的作用尚不清楚。在Ang-2-/-小鼠中实验性IBD的发展中观察到几个重要的差异。尽管WT和Ang-2-/- + DSS处理的小鼠中体重变化和疾病活动性仅略有不同，但与WT+ DSS小鼠相比，白细胞浸润、炎症以及血管和淋巴管密度显著减弱。与WT相比，Ang-2-/- + DSS小鼠的肠道毛细血管脆性和水排出（粪便血液和形式）显著更早出现。与WT + DSS相比，在Ang-2-/-中结肠长度也显著减少，并且在Ang-2-/-中肠组织病理学不太严重。最后，WT + DSS中血清蛋白含量的降低在Ang-2-/- + DSS中不太严重，因此蛋白丢失性肠病（PLE）（IBD的特征）被Ang-2-/-缓解。这些数据表明，在DSS结肠炎中，Ang-2介导炎性血管生成、淋巴管生成和中性粒细胞浸润以减少IBD的一些但不是全部临床特征。Ang-2操纵IBD和其他炎症性疾病的发展和治疗涉及Ang-2的影响进行了讨论。
The pathophysiology of inflammatory bowel disease (IBD) includes leukocyte infiltration, blood and lymphatic remodeling, weight loss and protein enteropathy. The roles of angiopoietin-2 (Ang-2) in initiating gut inflammation, leukocyte infiltration and angiogenesis are not well understood. Several important differences were seen in the development of experimental IBD in Ang-2-/- mice. Although weight change and disease activity differ only slightly in WT and Ang-2-/- + DSS treated mice, leukocyte infiltration, inflammation and blood and lymphatic vessel density is significantly attenuated compared to WT+ DSS mice. Gut capillary fragility and water export (stool blood and form) appear significantly earlier in Ang-2-/- + DSS mice vs. WT. Colon lengths were also significantly reduced in Ang-2-/- and gut histopathology was less severe in Ang-2-/-compared to WT + DSS. Lastly, the decrease in serum protein content in WT + DSS was less severe in Ang-2-/- + DSS, thus protein losing enteropathy (PLE) a feature of IBD is relieved by Ang-2-/-. These data demonstrate that in DSS colitis, Ang-2 mediates inflammatory hemangiogenesis, lymphangiogenesis and neutrophil infiltration to reduce some, but not all clinical features of IBD. The implications for Ang-2 manipulation in the development of IBD and other inflammatory diseases and treatments involving Ang-2 are discussed.
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影响因子：
11.8
作者：
Gale, NW;Thurston, G;Yancopoulos, GD
通讯作者：
Yancopoulos, GD
影响因子：
4.9
作者：
Ando, T;Jordan, P;Alexander, JS
通讯作者：
Alexander, JS
影响因子：
1.2
作者：
Kaneko, Hiroto;Yamashita, Mihoko;Taniwaki, Masafumi
通讯作者：
Taniwaki, Masafumi
DOI：
10.1196/annals.1326.003
发表时间：
2006-01-01
期刊：
INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS
影响因子：
--
作者：
Hatoum, Ossama A.;Heidemann, Jan;Binion, David G.
通讯作者：
Binion, David G.
影响因子：
4.8
作者：
Lee, HJ;Cho, CH;Koh, GY
通讯作者：
Koh, GY