Endometrial intraepithelial carcinoma in association with polyp: review of eight cases.
Endometrial intraepithelial carcinoma in association with polyp: review of eight cases.
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DOI：
10.1186/1746-1596-8-25
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发表时间：
2013-02-15
影响因子：
2.6
通讯作者：
Kameda Y
中科院分区：
文献类型：
--
作者：
Yasuda M;Katoh T;Hori S;Suzuki K;Ohno K;Maruyama M;Matsui N;Miyazaki S;Ogane N;Kameda Y
子宫内膜息肉（EMP）有发展为恶性肿瘤的潜在风险，尤其是在绝经后妇女。这些恶性肿瘤包括子宫内膜上皮内癌（EIC）。EMP中8例EIC患者，绝经后，年龄范围为49至76岁（平均62），进行细胞学审查与组织学结果进行比较。子宫内膜细胞学检查结果总结如下：粘液和水样质作为背景，缺乏或几乎没有坏死性炎症变化;微乳头簇形成;癌细胞和正常细胞之间的突然转变;核增大; N/C比率高;单个或少数突出的核仁。组织学上，1例EIC单独在EMP; 3例EIC与间质浸润局限于EMP;和4例EIC在萎缩的子宫内膜除了EIC在EMP。7名患者在手术切除后接受了无病治疗，但1名患者在初步诊断后44个月死亡，因为巨大的肿瘤延伸到她的腹膜腔。子宫内膜细胞学检查可能有助于发现具有浆液性特征的早期子宫内膜腺癌，包括EIC。以EIC为代表的一些早期子宫内膜腺癌，无论是否有宫外病变，其临床病程都异常具有侵袭性。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/1651876760876449
The uterine endometrial polyp (EMP) has a potential risk of developing malignant tumors especially in postmenopausal women. These malignancies include endometrial intraepithelial carcinoma (EIC). Eight patients with EIC in the EMP, who were postmenopausal with ages ranging from 49 to 76 years (av. 62), were cytologically reviewed in comparison with histological findings. The endometrial cytological findings were summarized as follows: mucous and watery diathesis as a background lacking or with little necrotic inflammatory changes; micropapillary cluster formation; abrupt transition between carcinoma cells and normal cells; nuclear enlargement; high N/C ratio; and single or a few prominent nucleoli. Histologically, one case had EIC alone in the EMP; three cases had EIC with stromal invasion confined to the EMP; and four cases had EIC in the atrophic endometrium in addition to EIC in the EMP. Seven patients have taken a disease-free course after surgical resection, but one patient died 44 months following the initial diagnosis because of the massive tumor extending over her peritoneal cavity. Endometrial cytology may be helpful for the detection of early endometrial adenocarcinomas with serous features including EIC. Some early stage endometrial adenocarcinomas represented by EIC exceptionally take an aggressive clinical course irrespective of a lack of extrauterine lesions. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1651876760876449
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影响因子：
5.6
作者：
SPIEGEL, GW
通讯作者：
SPIEGEL, GW
影响因子：
2.6
作者：
Sarmadi S;Izadi-Mood N;Sotoudeh K;Tavangar SM
通讯作者：
Tavangar SM
影响因子：
5.6
作者：
Wheeler, DT;Bell, KA;Sherman, ME
通讯作者：
Sherman, ME
DOI：
10.1016/j.ejogrb.2004.02.002
发表时间：
2004-08-10
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
Ben-Arie, A;Goldchmit, C;Hagay, Z
通讯作者：
Hagay, Z
影响因子：
7.5
作者：
Hui, P;Kelly, M;Schwartz, PE
通讯作者：
Schwartz, PE