The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period.
The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period.
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DOI：
10.3389/fncir.2022.939235
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发表时间：
2022
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
前额叶皮层在控制复杂的认知过程中起着核心作用，包括行动控制和决策。它还显示了与青春期独特行为变化相关的延迟成熟的特定模式，并允许成人认知过程的发展。青少年的大脑可塑性极强，极易受到外界的伤害。与这种脆弱性有关，青春期也与许多涉及前额叶功能改变的神经精神障碍的出现有关。在前额叶微回路中，多巴胺和内源性大麻素系统对多巴胺特异性个体发育过程具有广泛的影响。在这篇综述中，我们强调了最近的进展，在我们的理解成熟的多巴胺系统和内源性大麻素系统在前额叶皮层在青春期。我们讨论了它们如何与GABA和谷氨酸神经元相互作用来调节前额叶回路，以及它们如何被不同的环境事件改变，从而导致成年后的长期神经生物学和行为变化。最后，我们的目标是确定几个未来的研究方向，以帮助突出我们目前对这些微电路的成熟知识的差距。
The prefrontal cortex plays a central role in the control of complex cognitive processes including action control and decision making. It also shows a specific pattern of delayed maturation related to unique behavioral changes during adolescence and allows the development of adult cognitive processes. The adolescent brain is extremely plastic and critically vulnerable to external insults. Related to this vulnerability, adolescence is also associated with the emergence of numerous neuropsychiatric disorders involving alterations of prefrontal functions. Within prefrontal microcircuits, the dopamine and the endocannabinoid systems have widespread effects on adolescent-specific ontogenetic processes. In this review, we highlight recent advances in our understanding of the maturation of the dopamine system and the endocannabinoid system in the prefrontal cortex during adolescence. We discuss how they interact with GABA and glutamate neurons to modulate prefrontal circuits and how they can be altered by different environmental events leading to long-term neurobiological and behavioral changes at adulthood. Finally, we aim to identify several future research directions to help highlight gaps in our current knowledge on the maturation of these microcircuits.
影响因子：
3.3
作者：
Teegarden, S. L.;Scott, A. N.;Bale, T. L.
通讯作者：
Bale, T. L.