Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis.
Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis.
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DOI：
10.5588/ijtld.16.0510
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发表时间：
2017-07-01
期刊：
影响因子：
--
通讯作者：
Kato-Maeda M
中科院分区：
文献类型：
--
作者：
Feng JY;Jarlsberg LG;Salcedo K;Rose J;Janes M;Lin SG;Osmond DH;Jost KC;Soehnlen MK;Flood J;Graviss EA;Desmond E;Moonan PK;Nahid P;Hopewell PC;Kato-Maeda M
结核分枝杆菌的遗传特征对耐多药结核病（MDR-TB）聚集的影响尚未与临床和人口统计学特征一起分析。确定社区研究中与耐多药结核基因型聚集相关的因素。我们测量了耐多药结核病患者中聚集性病例的比例，并确定了临床和人口统计学特征以及三种耐多药结核病的影响。结核病遗传特征：谱系、耐药相关突变、rpoA和rpoC补偿突变。在来自加州和德克萨斯州的174名患者中，东亚、欧美、印度洋和东非-印度M.结核分支分别为70例（40.2%）、69例（39.7%）、33例（19.0%）和2例（1.1%）。与异烟肼和利福平耐药相关的最常见突变分别为katG S315 T和rpoB S531 L。在35株（20.1%）中发现了rpoA和rpoC的潜在补偿突变。西班牙裔（OR 26.50，95%CI 3.73-386.80），感染东亚型M。结核病家系（OR 30.00，95%CI 4.20-462.40）和rpoB突变S531 L（OR 4.03，95%CI 1.05-23.10）是与基因型聚集相关的独立因素。在所研究的细菌因素中，东亚血统和rpoB S531 L突变与基因型聚类独立相关，表明细菌因素对M.结核病导致继发病例。
The impact of the genetic characteristics of Mycobacterium tuberculosis on the clustering of multi-drug-resistant tuberculosis (MDR-TB) has not been analyzed together with clinical and demographic characteristics. To determine factors associated with genotypic clustering of MDR-TB in a community-based study. We measured the proportion of clustered cases among MDR-TB patients and determined the impact of clinical and demographic characteristics and that of three M. tuberculosis genetic characteristics: lineage, drug resistance-associated mutations, and rpoA and rpoC compensatory mutations. Of 174 patients from California and Texas included in the study, the number infected by East-Asian, Euro-American, Indo-Oceanic and East-African-Indian M. tuberculosis lineages were respectively 70 (40.2%), 69 (39.7%), 33 (19.0%) and 2 (1.1%). The most common mutations associated with isoniazid and rifampin resistance were respectively katG S315T and rpoB S531L. Potential compensatory mutations in rpoA and rpoC were found in 35 isolates (20.1%). Hispanic ethnicity (OR 26.50, 95%CI 3.73–386.80), infection with an East-Asian M. tuberculosis lineage (OR 30.00, 95%CI 4.20–462.40) and rpoB mutation S531L (OR 4.03, 95%CI 1.05–23.10) were independent factors associated with genotypic clustering. Among the bacterial factors studied, East-Asian lineage and rpoB S531L mutation were independently associated with genotypic clustering, suggesting that bacterial factors have an impact on the ability of M. tuberculosis to cause secondary cases.
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影响因子：
16.6
作者：
Eldholm, Vegard;Monteserin, Johana;Rieux, Adrien;Lopez, Beatriz;Sobkowiak, Benjamin;Ritacco, Viviana;Balloux, Francois
通讯作者：
Balloux, Francois
影响因子：
30.8
作者：
Comas, Inaki;Borrell, Sonia;Roetzer, Andreas;Rose, Graham;Malla, Bijaya;Kato-Maeda, Midori;Galagan, James;Niemann, Stefan;Gagneux, Sebastien
通讯作者：
Gagneux, Sebastien
影响因子：
9.4
作者：
Niemann, Stefan;Diel, Roland;Tang, Yi-Wei
通讯作者：
Tang, Yi-Wei
影响因子：
4.9
作者：
Ajbani, Kanchan;Lin, Shou-Yean Grace;Rodwell, Timothy C.
通讯作者：
Rodwell, Timothy C.
影响因子：
5.2
作者：
Brandis, Gerrit;Hughes, Diarmaid
通讯作者：
Hughes, Diarmaid