Association of DNA repair genes polymorphisms and mutations with increased risk of head and neck cancer: a review.
Association of DNA repair genes polymorphisms and mutations with increased risk of head and neck cancer: a review.
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DOI：
10.1007/s12032-017-1057-4
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发表时间：
2017-11-15
期刊：
影响因子：
--
通讯作者：
Suchorska WM
中科院分区：
文献类型：
--
作者：
Dylawerska A;Barczak W;Wegner A;Golusinski W;Suchorska WM
DNA修复机制可以维持基因组的稳定性和细胞内的正常功能。任何异常都可能导致患癌症等多种疾病的风险增加。头颈部鳞状细胞癌最关键的危险因素是行为因素，主要是长期接触烟草、酗酒和感染人乳头瘤病毒或爱泼斯坦-巴尔病毒。这些制剂会导致DNA损伤；因此，细胞必须激活适当的机制才能正常发挥作用。癌细胞具有基因组不稳定的特点，这与DNA损伤积累的更大趋势以及化疗和放射耐药性的增加有关。多项研究评估了头颈部癌(HNC)风险增加与DNA修复基因多态性的相关性。然而，他们认为DNA修复基因突变与HNC易感性的相互作用取决于患者的种族和风险因素，特别是吸烟。必须对这些序列变异进行进一步鉴定。在这篇综述中，我们讨论了DNA修复基因突变和多态与头颈部治疗的高风险相关的现有知识。
DNA repair mechanisms allow maintain genomic stability and proper functioning within the cells. Any aberrations may cause an increased risk of many diseases such as cancer. The most crucial risk factors for head and neck squamous cell carcinoma are behavioral factors, predominantly chronic exposure to tobacco, alcohol addiction, and infection with human papillomavirus or Epstein–Barr virus. These agents can induce DNA damage; therefore, cells must activate appropriate mechanisms in order to function correctly. Cancer cells are marked with genomic instability, which is associated with a greater tendency for the accumulation of a DNA damage and increased chemo- and radioresistance. Multiple studies have assessed the correlation of increased head and neck cancer (HNC) risk with polymorphism in the DNA repair genes. However, they suggest that interaction of DNA repair genes mutations with susceptibility to HNC depends on a patient’s race and risk factors, especially tobacco smoking. Further identification of these sequence variations must be performed. In this review, we discuss the current knowledge about the DNA repair genes mutations and polymorphisms associated with the high risk of head and neck treatment.
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DOI：
10.1186/1758-3284-1-36
发表时间：
2009-10-14
期刊：
Head & neck oncology
影响因子：
--
作者：
Goon PK;Stanley MA;Ebmeyer J;Steinsträsser L;Upile T;Jerjes W;Bernal-Sprekelsen M;Görner M;Sudhoff HH
通讯作者：
Sudhoff HH
影响因子：
6.6
作者：
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通讯作者：
Bartek, Jiri
影响因子：
3.8
作者：
Farnebo, Lovisa;Stjernstrom, Annika;Thunell, Lena K.
通讯作者：
Thunell, Lena K.
影响因子：
--
作者：
Cirauqui, B.;Margeli, M.;Rosell, R.
通讯作者：
Rosell, R.
影响因子：
--
作者：
Kayani, Mahmood Akhtar;Khan, Sumeera;Mahjabeen, Ishrat
通讯作者：
Mahjabeen, Ishrat