The actin cytoskeleton in hair bundle development and hearing loss.
The actin cytoskeleton in hair bundle development and hearing loss.
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DOI：
10.1016/j.heares.2023.108817
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发表时间：
2023-09-01
期刊：
影响因子：
2.8
通讯作者：
Bird, Jonathan E.
中科院分区：
文献类型：
--
作者：
Park, Jinho;Bird, Jonathan E.
内耳毛细胞在其顶端表面组装机械敏感的毛束，以抑制声音和加速度。每个毛束由约100个单独的静纤毛组成，静纤毛排列成高度和宽度逐渐增加的行;它们的特定和精确的结构是机械电转换（MET）所必需的。肌动蛋白细胞骨架是建立这种结构的基础，不仅通过形成形成每个静纤毛的结构支架，而且通过组成小根和表皮板，它们一起提供支撑每个静纤毛的稳定基础。与肌动蛋白细胞骨架一致，大量肌动蛋白结合蛋白（ABP）的功能是将肌动蛋白丝交联成特定的拓扑结构，以及控制肌动蛋白丝的生长、切断和加帽。这些过程对于感觉传导是单独关键的，并且在人类听力损失的遗传形式中全部被破坏。在这篇综述中，我们提供了一个概述肌动蛋白为基础的结构在头发束和分子有助于他们的组装和功能特性。我们还强调了最近的进展，机制驱动静纤毛伸长，以及这些过程是如何调整MET。
Inner ear hair cells assemble mechanosensitive hair bundles on their apical surface that transduce sounds and accelerations. Each hair bundle is comprised of ~ 100 individual stereocilia that are arranged into rows of increasing height and width; their specific and precise architecture being necessary for mechanoelectrical transduction (MET). The actin cytoskeleton is fundamental to establishing this architecture, not only by forming the structural scaffold shaping each stereocilium, but also by composing rootlets and the cuticular plate that together provide a stable foundation supporting each stereocilium. In concert with the actin cytoskeleton, a large assortment of actin-binding proteins (ABPs) function to cross-link actin filaments into specific topologies, as well as control actin filament growth, severing, and capping. These processes are individually critical for sensory transduction and are all disrupted in hereditary forms of human hearing loss. In this review, we provide an overview of actin-based structures in the hair bundle and the molecules contributing to their assembly and functional properties. We also highlight recent advances in mechanisms driving stereocilia elongation and how these processes are tuned by MET.
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DOI：
10.1083/jcb.201704171
发表时间：
2017-11-06
期刊：
The Journal of cell biology
影响因子：
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作者：
Avenarius MR;Krey JF;Dumont RA;Morgan CP;Benson CB;Vijayakumar S;Cunningham CL;Scheffer DI;Corey DP;Müller U;Jones SM;Barr-Gillespie PG
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DOI：
10.1002/cm.21719
发表时间：
2022-06
期刊：
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影响因子：
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DOI：
10.1002/cm.21227
发表时间：
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期刊：
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影响因子：
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