Cognitive Dysfunction, Psychiatric Distress, and Functional Decline After COVID-19.
Cognitive Dysfunction, Psychiatric Distress, and Functional Decline After COVID-19.
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DOI：
10.1016/j.jaclp.2021.10.006
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发表时间：
2022-03
影响因子：
2.3
通讯作者：
Oh ES
中科院分区：
文献类型：
--
作者：
Vannorsdall TD;Brigham E;Fawzy A;Raju S;Gorgone A;Pletnikova A;Lyketsos CG;Parker AM;Oh ES
对新冠肺炎在急性后阶段的认知和精神后遗症的了解有限，特别是在种族和民族多元化的患者中。目的：我们试图在一组种族和民族不同的患者中，在最初诊断为新冠肺炎大约四个月后，前瞻性地描述认知、心理健康症状和功能的特征。在新冠肺炎确诊约四个月后，约翰霍普金斯大学急性新冠肺炎团队肺部诊所的患者接受了基于电话的临床认知、抑郁、焦虑、创伤和功能评估。约翰霍普金斯大学急性新冠肺炎研究小组评估的大多数患者是女性(59%)和种族/少数民族成员(65%)。在82名患者中，67%的患者≥-1认知评分异常低。需要重症监护病房(ICU)的患者比那些需要较少强化治疗的患者表现出更大的损伤广度和严重程度。处理速度(35%)、语言流畅性(26%-32%)、学习(27%)和记忆力(27%)是最常见的障碍。在所有患者中，35%的患者有中度抑郁(23%)、焦虑(15%)或功能下降(15%)的症状；25%的ICU患者报告与创伤相关的痛苦。神经精神症状和功能下降在ICU后和非ICU状态下没有差异，也与总体认知综合评分无关。在急性疾病后大约4个月，认知功能障碍、情绪困扰和功能下降在不同急性疾病严重程度的新冠肺炎幸存者的不同临床样本中很常见。需要留在ICU的患者比那些需要较少强化治疗的患者表现出更大的认知障碍广度和严重程度。研究结果有助于扩大我们对新冠肺炎后神经精神疾病发病率的性质、严重性和潜在持续时间的理解，并指出有必要对不同人口背景和疾病特征的新冠肺炎幸存者的认知和心理健康结果进行纵向评估。
There is a limited understanding of the cognitive and psychiatric sequelae of COVID-19 during the post-acute phase, particularly among racially and ethnically diverse patients. Objective: We sought to prospectively characterize cognition, mental health symptoms, and functioning approximately four months after an initial diagnosis of COVID-19 in a racially and ethnically diverse group of patients. Approximately four months after COVID-19 diagnosis, patients in the Johns Hopkins Post-Acute COVID-19 Team Pulmonary Clinic underwent a clinical telephone-based assessment of cognition, depression, anxiety, trauma, and function. Most Johns Hopkins Post-Acute COVID-19 Team patients assessed were women (59%) and members of racial/ethnic minority groups (65%). Of 82 patients, 67% demonstrated ≥1 abnormally low cognitive score. Patients requiring intensive care unit (ICU) stays displayed greater breadth and severity of impairment than those requiring less intensive treatment. Processing speed (35%), verbal fluency (26%–32%), learning (27%), and memory (27%) were most commonly impaired. Among all patients, 35% had moderate symptoms of depression (23%), anxiety (15%), or functional decline (15%); 25% of ICU patients reported trauma-related distress. Neuropsychiatric symptoms and functional decline did not differ by post-ICU versus non-ICU status and were unrelated to global cognitive composite scores. At approximately 4 months after acute illness, cognitive dysfunction, emotional distress, and functional decline were common among a diverse clinical sample of COVID-19 survivors varying in acute illness severity. Patients requiring ICU stays demonstrated greater breadth and severity of cognitive impairment than those requiring less intensive treatment. Findings help extend our understanding of the nature, severity, and potential duration of neuropsychiatric morbidity after COVID-19 and point to the need for longitudinal assessment of cognitive and mental health outcomes among COVID-19 survivors of different demographic backgrounds and illness characteristics.
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DOI：
10.1186/s13195-020-00744-w
发表时间：
2020-12-30
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Miners S;Kehoe PG;Love S
通讯作者：
Love S
影响因子：
15.1
作者：
Hosey, Megan M.;Leoutsakos, Jeannie-Marie S.;Neufeld, Karin J.
通讯作者：
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用经验方法确定具有多种测量方法的测试组合的异常标准
影响因子：
2.4
作者：
Ingraham, LJ;Aiken, CB
通讯作者：
Aiken, CB
影响因子：
3.8
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Mcloughlin, Benjamin C.;Miles, Amy;Davis, Daniel
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Davis, Daniel
影响因子：
2.6
作者：
Matchanova, Anastasia;Babicz, Michelle A.;Woods, Steven Paul
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Woods, Steven Paul