Astrocyte Mitochondria in White-Matter Injury.
Astrocyte Mitochondria in White-Matter Injury.
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DOI：
10.1007/s11064-021-03239-8
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发表时间：
2021-10
影响因子：
4.4
通讯作者：
Baltan S
中科院分区：
文献类型：
--
作者：
Nguyen H;Zerimech S;Baltan S
本文综述了星形胶质细胞的不同结构和功能，以描述位于不同位置的星形胶质细胞所需要的生物能量多样性。星形胶质细胞线粒体的细胞间结构域决定了它们在支持和调节星形胶质细胞-神经元偶联和抗缺血存活中的作用。星形胶质细胞线粒体的异质性，以及星形胶质细胞线粒体亚群如何适应与其他胶质细胞相互作用并调节轴突功能，需要进一步研究。很明显，线粒体通透性过渡孔在多种人类疾病中起关键作用，其共同病理可能基于Ca2+触发的线粒体功能障碍和氧化应激增强。活性氧引起轴突变性和轴突运输减少，导致轴突营养不良和神经变性，包括阿尔茨海默病、肌萎缩性侧索硬化症、帕金森病和亨廷顿病。开发新的工具，以便更好地研究星形胶质细胞中的线粒体结构和功能，以及专门针对星形胶质细胞线粒体的技术，可以帮助揭示线粒体健康和功能障碍在神经元细胞之外更广泛的背景下的作用。总之，本综述将评估星形细胞线粒体作为减轻中枢神经系统急性和慢性损伤的治疗靶点的价值。
This review summarizes the diverse structure and function of astrocytes to describe the bioenergetic versatility required of astrocytes that are situated at different locations. The intercellular domain of astrocyte mitochondria defines their roles in supporting and regulating astrocyte-neuron coupling and survival against ischemia. The heterogeneity of astrocyte mitochondria, and how subpopulations of astrocyte mitochondria adapt to interact with other glia and regulate axon function, require further investigation. It has become clear that mitochondrial permeability transition pores play a key role in a wide variety of human diseases, whose common pathology may be based on mitochondrial dysfunction triggered by Ca2+ and potentiated by oxidative stress. Reactive oxygen species cause axonal degeneration and a reduction in axonal transport, leading to axonal dystrophies and neurodegeneration including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, and Huntington’s disease. Developing new tools to allow better investigation of mitochondrial structure and function in astrocytes, and techniques to specifically target astrocyte mitochondria, can help to unravel the role of mitochondrial health and dysfunction in a more inclusive context outside of neuronal cells. Overall, this review will assess the value of astrocyte mitochondria as a therapeutic target to mitigate acute and chronic injury in the CNS.
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影响因子：
5.3
作者：
Burda JE;Bernstein AM;Sofroniew MV
通讯作者：
Sofroniew MV
影响因子：
5.3
作者：
Abramov, AY;Canevari, L;Duchen, MR
通讯作者：
Duchen, MR
影响因子：
56.9
作者：
Bindocci, Erika;Savtchouk, Iaroslav;Volterra, Andrea
通讯作者：
Volterra, Andrea
DOI：
10.1083/jcb.145.4.795
发表时间：
1999-05-17
期刊：
The Journal of cell biology
影响因子：
--
作者：
Boitier E;Rea R;Duchen MR
通讯作者：
Duchen MR
影响因子：
16.2
作者：
Agarwal A;Wu PH;Hughes EG;Fukaya M;Tischfield MA;Langseth AJ;Wirtz D;Bergles DE
通讯作者：
Bergles DE