Cryptosporidium species and subtypes and clinical manifestations in children, Peru.
Cryptosporidium species and subtypes and clinical manifestations in children, Peru.
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DOI：
10.3201/eid1410.071273
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发表时间：
2008-10
影响因子：
11.8
通讯作者：
Xiao L
中科院分区：
文献类型：
--
作者：
Cama VA;Bern C;Roberts J;Cabrera L;Sterling CR;Ortega Y;Gilman RH;Xiao L
一句话总结目录：不同的基因型和亚型与不同的临床表现有关。为了确定临床表现是否与隐孢子虫属的基因型或亚型有关，我们研究了秘鲁的533名儿童的4年纵向出生队列。在109名儿童中共发现156例感染。首次感染的数据表明，C。人感染与腹泻、恶心、呕吐、全身不适和卵囊排出强度和持续时间增加有关。与之相反，C. parvum、小隐翅虫C. Escherichiagridis，C. canis和C.猫只与腹泻有关。C.人亚型家族被鉴定（Ia、Ib、Id和Ie）;所有人亚型家族都与腹泻相关。Ib还与恶心、呕吐和全身不适相关。全是C。parvum标本属于Ⅱ c亚型。风险因素分析未显示与特定隐孢子虫属相关。基因型或亚型。这些发现强烈表明隐孢子虫属。亚型与儿童的不同临床表现有关。
One-sentence summary for table of contents: Different genotypes and subtypes are linked to different clinical manifestations. To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children.
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影响因子：
11.8
作者：
Bern C;Ortega Y;Checkley W;Roberts JM;Lescano AG;Cabrera L;Verastegui M;Black RE;Sterling C;Gilman RH
通讯作者：
Gilman RH
影响因子：
3.2
作者：
Gatei, Wangeci;Das, Pradeep;Xiao, Lihua
通讯作者：
Xiao, Lihua
DOI：
10.4269/ajtmh.1984.33.24
发表时间：
1984-01-01
影响因子：
3.3
作者：
MATA, L;BOLANOS, H;VIVES, M
通讯作者：
VIVES, M
影响因子：
3.3
作者：
Raccurt, Christian P.;Brasseur, Philippe;Pape, Jean W.
通讯作者：
Pape, Jean W.
影响因子：
2.1
作者：
Samie, A.;Bessong, P. O.;Guerrant, R. L.
通讯作者：
Guerrant, R. L.