Inflammatory markers in population studies of aging.

Inflammatory markers in population studies of aging.
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DOI:
10.1016/j.arr.2010.11.002
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发表时间:
2011-07
影响因子:
13.1
通讯作者:
Newman, Anne B.
Newman, Anne B.
中科院分区:
医学1区
文献类型:
--
作者:
Singh, Tushar;Newman, Anne B.

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回顾关于老年人炎症标志物升高的危险因素和后果的主要流行病学研究结果。目前大多数大型老年人流行病学研究包括血清白细胞介素-6(IL-6)、C反应蛋白(CRP)和肿瘤坏死因子α(TNF-α),以及一些更广泛的测量方法,包括可溶性受体。随着年龄的增长,很少有风险因素被确定,包括内脏肥胖,性类固醇激素水平降低,吸烟和抑郁症。在评估的标志物中,IL-6与疾病、残疾和死亡率的相关性最强。IL-6是老年人不良结局的非特异性标志物。
To review findings from major epidemiologic studies regarding risk factors and consequences of elevated markers of inflammation in older adults. Most of the large, current epidemiologic studies of older adults have included serum interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-alpha), and some more extensive batteries of measures including soluble receptors. Few risk factors for the modest elevations seen with aging have been defined, including, visceral adiposity, lower sex steroid hormones, smoking, and depression. Of the markers assessed, IL-6 is most robustly associated with disease, disability and mortality. IL-6 is a non-specific marker of adverse outcomes in older adults.
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