C-reactive protein and lipid parameters in older persons aged 80 years and older.
C-reactive protein and lipid parameters in older persons aged 80 years and older.
复制标题
DOI：
10.1007/s12603-009-0168-9
复制
发表时间：
2009-08
影响因子：
5.8
通讯作者：
Landi, F.
中科院分区：
文献类型：
--
作者：
Cesari, M.;Onder, G.;Zamboni, V.;Capoluongo, E.;Russo, A.;Bernabei, R.;Pahor, M.;Landi, F.
本研究的目的是：1)研究c反应蛋白（CRP）与脂质（即总胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇、甘油三酯）浓度的关系，并评估它们对高龄受试者死亡率的预测价值。前瞻性队列研究的横断面和纵向分析。数据来自336名年龄≥80岁的社区居民，他们参加了“长寿长寿”（ilSIRENTE）研究。在基线临床访问时测量高敏CRP和脂质浓度。ELISA法检测高敏CRP浓度。在24个月的随访中评估死亡率结果。参与者的平均年龄为85.8岁（SD 4.8）。Spearman相关性显示CRP与血脂参数（甘油三酯除外）呈显著负相关（p值<0.01）。调整后的线性回归显示，在年龄低于85岁的参与者中，CRP和脂质参数浓度之间没有显著的关联（p值均为>0.5）。在老年人群中，CRP与总胆固醇（p=0.002）、低密度脂蛋白（p=0.007）和高密度脂蛋白胆固醇（p=0.002）呈显著负相关，即使校正了潜在的混杂因素后也是如此。校正后的Cox比例风险模型显示，CRP是唯一能独立于年龄和血脂参数，显著预测死亡率的生物标志物。在老年人中，总胆固醇、低密度脂蛋白和高密度脂蛋白与CRP呈负相关。CRP的预后价值在老年人中尤为重要，而脂质参数往往失去其预测事件的能力。
Aims of the study were 1) to investigate the association of C-reactive protein (CRP) with lipid (i.e. total, LDL, and HDL cholesterol, triglycerides) concentrations, and to evaluate their predictive value for mortality in very old subjects. Cross-sectional and longitudinal analyses in a prospective cohort study. Data are from 336 community-dwelling subjects aged ≥80 years old enrolled in the “Invecchiamento e Longevita' nel Sirente” (ilSIRENTE) study. High sensitivity CRP and lipid concentrations were measured at the baseline clinical visit. High sensitivity CRP concentrations were measured by ELISA assessment. Mortality outcome was evaluated over a 24-month follow-up. Participants had a mean age of 85.8 (SD 4.8) years old. Spearman's correlations showed significant (p values <0.01) inverse correlations between CRP and lipid parameters (except triglycerides). Adjusted linear regressions between CRP and lipid parameters concentrations showed no significant association in participants aged lower than 85 years old (all p values >0.5). In the older age group, significant inverse associations of CRP with total (p=0.002), LDL (p=0.007), and HDL cholesterol (p=0.002) were found, even after adjustment for potential confounders. Adjusted Cox proportional hazard models demonstrated that CRP was the only biomarker significantly predictive of mortality, independently of age and lipid parameters. An inverse relationship of total, LDL, and HDL cholesterol with CRP is present in very old persons. The prognostic value of CRP is particularly important among very old persons whereas lipid parameters tend to lose their capacity to predict events.
登录
查看更多内容
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
影响因子：
5.9
作者：
Cohen, HJ;Harris, T;Pieper, CF
通讯作者：
Pieper, CF
影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F
影响因子：
2.7
作者：
Casiglia, E;Palatini, P
通讯作者：
Palatini, P
影响因子：
--
作者：
KRONMAL, RA;CAIN, KC;OMENN, GS
通讯作者：
OMENN, GS