Impaired automatic and unconscious motor processes in Parkinson's disease.

Impaired automatic and unconscious motor processes in Parkinson's disease.
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DOI:
10.1038/srep02095
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发表时间:
2013
期刊:
影响因子:
4.6
通讯作者:
Garraux, Gaetan
Garraux, Gaetan
中科院分区:
综合性期刊3区
文献类型:
--
作者:
D'Ostilio, Kevin;Cremers, Julien;Delvaux, Valerie;Sadzot, Bernard;Garraux, Gaetan

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虽然人们越来越认识到自愿运动是由有意识和无意识过程之间的相互作用产生的,但后者在帕金森病中的作用迄今为止很少受到关注。在这里,我们对15名帕金森病患者和15名年龄匹配的健康老年人进行了阈下隐藏启动任务。通过控制箭头方向和刺激间隔来检验相容性效应。对正相容性效应的分析揭示了帕金森病患者受影响最大的手和最小的手之间的表现差异。此外,与老年对照相比,患者没有表现出同样的负相容性效应倾向。这些新发现提供了支持基底神经节回路在控制自动运动反应促进和抑制之间平衡中的作用的证据。
While it is increasingly recognized that voluntary movements are produced by an interaction between conscious and unconscious processes, the role of the latter in Parkinson's disease has received little attention to date. Here, we administered a subliminal masked prime task to 15 Parkinson's disease patients and 15 age-matched healthy elderly subjects. Compatibility effects were examined by manipulating the direction of the arrows and the interstimuli interval. Analysis of the positive compatibility effect revealed performance differences between the most and the least affected hand in Parkinson's disease patients. Additionally, patients did not show the same tendency toward a negative compatibility effect as compared to elderly controls. These novel findings provide evidence supporting the role of basal ganglia circuits in controlling the balance between automatic motor response facilitation and inhibition.
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