Somatosensory cortical signature of facial nociception and vibrotactile touch-induced analgesia.
Somatosensory cortical signature of facial nociception and vibrotactile touch-induced analgesia.
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DOI：
10.1126/sciadv.abn6530
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发表时间：
2022-11-18
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
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通过振动触觉来缓解疼痛是一种常见的人类体验。先前对其潜在机制的动物神经生理学研究主要集中在脊髓回路上，而人类研究表明涉及棘上通路。在这里，我们研究初级体感觉皮层（S1）在触觉诱导的机械和热镇痛中的作用。我们发现，在小鼠中，自产生的振动触觉再传入信号显著减少了面部伤害感觉，这种伤害感觉通过特异性地阻断从丘脑到桶状皮质的触觉传递而被消除（S1B）。我们使用一种信号分离算法，将钙信号分解为感觉诱发反应、微拂反应或擦脸反应，发现微拂的存在改变了S1B神经元的伤害性信号处理。对S1B种群动态的分析表明，拂动推动由有害刺激引起的神经状态向非有害行为的结果转变。因此，S1B整合了面部触觉和有害信号，从而实现触觉介导的镇痛。触觉振动信号在触觉介导的面部镇痛过程中调节桶状皮质种群动态。
Pain relief by vibrotactile touch is a common human experience. Previous neurophysiological investigations of its underlying mechanism in animals focused on spinal circuits, while human studies suggested the involvement of supraspinal pathways. Here, we examine the role of primary somatosensory cortex (S1) in touch-induced mechanical and heat analgesia. We found that, in mice, vibrotactile reafferent signals from self-generated whisking significantly reduce facial nociception, which is abolished by specifically blocking touch transmission from thalamus to the barrel cortex (S1B). Using a signal separation algorithm that can decompose calcium signals into sensory-evoked, whisking, or face-wiping responses, we found that the presence of whisking altered nociceptive signal processing in S1B neurons. Analysis of S1B population dynamics revealed that whisking pushes the transition of the neural state induced by noxious stimuli toward the outcome of non-nocifensive actions. Thus, S1B integrates facial tactile and noxious signals to enable touch-mediated analgesia. Vibrotactile signals modulate barrel cortex population dynamics during touch mediated facial analgesia.
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影响因子：
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