Increased Prevalence of Thalassemia in Young People in Korea: Impact of Increasing Immigration.
Increased Prevalence of Thalassemia in Young People in Korea: Impact of Increasing Immigration.
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DOI：
10.3343/alm.2019.39.2.133
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发表时间：
2019-03
影响因子：
4.9
通讯作者：
Seong MW
中科院分区：
文献类型：
--
作者：
Lee HJ;Shin KH;Kim HH;Yang EJ;Park KH;Kim MJ;Kwon JR;Choi YS;Kim JN;Shin MG;Cho YG;Kim SJ;Kim KH;Jeong S;Kong SG;Jung YJ;Lee N;Kim MJ;Seong MW
地中海贫血在东南亚非常普遍，但在韩国很少见;然而，东南亚移民人口最近在韩国上升。我们调查了地中海贫血的患病率在韩国的背景下，不断增加的移民。这项前瞻性、观察性、多中心研究于2015年9月至2017年8月进行。将居住在韩国的669名年龄<30岁的受试者分为多种族组（N=314）和韩国组（N=355）。进行Hb电泳和全血细胞计数（CBC）。如果观察到平均红细胞体积低，红细胞分布宽度变异系数高，或胎儿Hb（HbF）或Hb α 2（HbA 2）水平高，则进行α和β珠蛋白基因的遗传检测。此外，韩国潜在的地中海贫血携带者的数量是通过将特定种族的地中海贫血患病率乘以该种族的移民人数来估计的。26个多民族和10名韩国受试者显示异常结果的血红蛋白电泳和CBC。对18名多种族受试者和4名韩国受试者进行了α-珠蛋白和β-珠蛋白基因突变检测。在多种族组中，5例受试者（1.5%）为α-地中海贫血携带者，6例受试者（1.9%）为β-地中海贫血轻度携带者。HBA 1和HBA 2中的SEA缺失，以及c. HBB的126_129delCTTT（p.Phe42Leufs*19）突变为显性遗传突变。由于东南亚移民人数的增加，韩国年轻人中地中海贫血的患病率正在增加。
Thalassemia is highly prevalent in Southeast Asia but is rare in Korea; however, Southeast Asian immigrant population is recently rising in Korea. We investigated the prevalence of thalassemia in Korea in the context of increasing immigration. This prospective, observational, multicenter study was conducted between September 2015 and August 2017. A total of 669 subjects <30 years living in Korea were grouped into the multiethnic (N=314) and Korean (N=355) groups. Hb electrophoresis and complete blood count (CBC) were performed. If low mean corpuscular volume with high red blood cell distribution width coefficient of variation or a high fetal Hb (HbF) or Hb alpha 2 (HbA2) level was observed, genetic testing of the α- and β-globin genes was performed. In addition, the number of potential thalassemia carriers in Korea was estimated by multiplying the prevalence of thalassemia in a specific ethnicity by the number of immigrants of that ethnicity. Twenty-six multiethnic and 10 Korean subjects showed abnormal results for Hb electrophoresis and CBC. Eighteen multiethnic subjects and four Korean subjects were tested for α-globin and β-globin gene mutations. Within the multiethnic group, five subjects (1.5%) were α-thalassemia carriers, and six (1.9%) were β-thalassemia minor. The SEA deletion in HBA1 and HBA2, and c. 126_129delCTTT (p.Phe42Leufs*19) mutation of HBB were the dominant inherited mutations. The prevalence of thalassemia in young people in Korea is increasing due to the increasing number of Southeast Asian immigrants.
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影响因子：
2.4
作者：
Ferrari, Giuliana;Cavazzana, Marina;Mavilio, Fulvio
通讯作者：
Mavilio, Fulvio
影响因子：
3.1
作者：
Boonyawat, Boonchai;Monsereenusorn, Chalinee;Traivaree, Chanchai
通讯作者：
Traivaree, Chanchai
影响因子：
1
作者：
Huang, Hailong;Xu, Liangpu;Lin, Yuan
通讯作者：
Lin, Yuan
DOI：
10.17945/kjbt.2017.28.3.282
发表时间：
2017-01-01
期刊：
The Korean Journal of Blood Transfusion
影响因子：
--
作者：
HYUN-JI, LEE;Shin, Kyung-Hwa;Kim, HyungHoi
通讯作者：
Kim, HyungHoi
影响因子：
2.8
作者：
Mosca, Andrea;Paleari, Renata;Ivaldi, Giovanni
通讯作者：
Ivaldi, Giovanni