A case of relapsed Mycobacterium chelonae pulmonary infection presenting with severe weight loss and treated with a combination of antibiotic therapy and percutaneous feeding.
A case of relapsed Mycobacterium chelonae pulmonary infection presenting with severe weight loss and treated with a combination of antibiotic therapy and percutaneous feeding.
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DOI：
10.1016/j.jctube.2020.100209
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发表时间：
2021-03
影响因子：
2
通讯作者：
Alvarez GG
中科院分区：
文献类型：
--
作者：
Pease C;Alvarez GG
龟分枝杆菌是一种非结核分枝杆菌，最常与皮肤和软组织感染有关。我们提出了一个递归M的情况。龟类肺部感染表现为体重严重下降复发后，痰培养保持阳性2年，尽管适当的抗生素。只有在静脉内添加亚胺培南和空肠造口饲料后，培养才变为阴性。M的稀有性。龟类肺部感染意味着最佳治疗方案尚未完全确立，但已推荐克拉霉素加其他抗生素方案1。此类感染的预后也尚不清楚，但大环内酯类耐药率较低表明其预后可能优于密切相关的M。你好虽然其益处尚未得到证实，但营养补充，包括经皮肠内喂养，可以考虑用于体重不足患者的难治性NTM感染。
Mycobacterium chelonae is a type of nontuberculous mycobacteria most commonly associated with skin and soft tissue infections. We present a case of recurrent M. chelonae pulmonary infection presenting with severe weight loss. After recurrence, sputum cultures remained positive for 2 years despite appropriate antibiotics. Cultures only became negative after the addition of intravenous imipenem and jejunostomy feeds. The rarity of M. chelonae pulmonary infection means that optimal treatment regimens have not yet been fully established but a regimen of clarithromycin plus an additional antibiotic has been recommended1. The prognosis of such infections also remains unclear but lower rates of macrolide resistance suggest that the prognosis may be better than the closely related species M. abscessus. Although its benefit has not been proven, nutrition supplementation, including percutaneous enteral feeding, can be considered for refractory NTM infection in underweight patients.
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