Subfamily of Olfactory Receptors Characterized by Unique Structural Features and Expression Patterns
Subfamily of Olfactory Receptors Characterized by Unique Structural Features and Expression Patterns
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具有独特结构特征和表达模式的嗅觉受体亚科
DOI：
10.1046/j.1471-4159.1997.69020465.x
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发表时间：
1997
影响因子：
4.7
通讯作者：
H. Breer
中科院分区：
文献类型：
--
作者：
S. Kubick;J. Strotmann;I. Andreini;H. Breer
嗅觉系统复杂的化学特异性可能是由于在鼻神经上皮内广泛分布的神经元中表达的大家族短环七螺旋受体蛋白。在这项研究中，嗅觉受体的一个亚家族已经被确定，其特点是独特的结构特征和独特的表达模式。这种受体家族的成员存在于哺乳动物中，如啮齿动物和负鼠，但不存在于低等脊椎动物中。所有确定的亚型都包括一个扩展的第三细胞外环，该环具有两亲性，并在保守位置包含许多带电氨基酸。表达这些受体类型的嗅觉感觉神经元在中央鼻甲尖端分离成小簇，从而代表了嗅觉受体的一种新的表达模式。在小鼠中，编码新的受体亚家族的基因被发现隐藏在一个小的连续的基因组DNA片段中。基于物种特异性以及独特的结构特性和表达模式，可以想象新的受体亚家族可能在哺乳动物嗅觉系统中起着特殊的作用。
Abstract: The complex chemospecificity of the olfactory system is probably due to the large family of short‐looped, heptahelical receptor proteins expressed in neurons widely distributed throughout one of the several zones within the nasal neuroepithelium. In this study, a subfamily of olfactory receptors has been identified that is characterized by distinct structural features as well as a unique expression pattern. Members of this receptor family are found in mammals, such as rodents and opossum, but not in lower vertebrates. All identified subtypes comprise an extended third extracellular loop that exhibits amphiphilic properties and contains numerous charged amino acids in conserved positions. Olfactory sensory neurons expressing these receptor types are segregated in small clusters on the tip of central turbinates, thus representing a novel pattern of expression for olfactory receptors. In mouse, genes encoding the new subfamily of receptors were found to be harbored within a small contiguous segment of genomic DNA. Based on species specificity as well as the unique structural properties and expression pattern, it is conceivable that the novel receptor subfamily may serve a special function in the olfactory system of mammals.
大鼠粘膜固有的活动模式：来自电压敏感染料的证据。
影响因子：
2.5
作者：
Youngentob,SL;Kent,PF;Sheehe,PR;Schwob,JE;Tzoumaka,E
通讯作者：
Tzoumaka,E
小鼠促性腺激素释放激素受体的谷氨酸 301 赋予哺乳动物促性腺激素释放激素精氨酸 8 的特异性。
DOI：
--
发表时间：
1994
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Flanagan,CA;Becker,II;Davidson,JS;Wakefield,IK;Zhou,W;Sealfon,SC;Millar,RP
通讯作者：
Millar,RP