On developing a novel mixed-unit microparticle system for controlled release

On developing a novel mixed-unit microparticle system for controlled release
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开发新型混合单元控释微粒系统

DOI:
10.1080/07373937.2017.1402025
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发表时间:
2018-08
期刊:
影响因子:
3.3
通讯作者:
Zeneng Cheng
Zeneng Cheng
中科院分区:
工程技术3区
文献类型:
--
作者:
Wei Qiang;Wenjie Liu;Zeneng Cheng

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摘要本研究采用高效微流控喷雾干燥技术制备了均匀的微颗粒,并在此基础上开发了一种柔性控释混合单元微颗粒系统,以满足多种需求。建立了混合系统的药物释放数学模型,并在给定初始参数的情况下,用两种混合配方验证了其预测能力。结果表明,该模型能准确预测样品的释放速度。综上所述,该新型控释体系为修饰释放药物提供了新的选择,具有良好的工业应用前景。
ABSTRACT In this study, uniform microparticles were prepared using the highly efficient microfluidic spray drying technology, and then a flexible controlled release mixed-unit microparticle system was developed to meet various needs. A mathematical drug release model of the mixed system was established and two mixed formulations were used to testify the predictive ability when initial parameters were given. Results have proved that the proposed model could precisely predict the release rate of tested samples. In conclusion, the novel system for controlled release may provide a new option for modified release drugs and may have a good prospect in the industrial application.
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