Circadian rhythm reprogramming during lung inflammation.
Circadian rhythm reprogramming during lung inflammation.
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DOI：
10.1038/ncomms5753
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发表时间：
2014-09-11
影响因子：
16.6
通讯作者：
Choi, Augustine M. K.
中科院分区：
文献类型：
--
作者：
Haspel, Jeffrey A.;Chettimada, Sukrutha;Shaik, Rahamthulla S.;Chu, Jen-Hwa;Raby, Benjamin A.;Cernadas, Manuela;Carey, Vincent;Process, Vanessa;Hunninghake, G. Matthew;Ifedigbo, Emeka;Lederer, James A.;Englert, Joshua;Pelton, Ashley;Coronata, Anna;Fredenburgh, Laura E.;Choi, Augustine M. K.
众所周知，昼夜节律可以调节健康动物的免疫反应，但尚不清楚它们是否会在急性疾病中持续存在，在急性疾病中，时钟基因的表达会受到全身炎症的干扰。在这里，我们使用全基因组的方法来研究内毒素血症小鼠肺部的昼夜节律基因和代谢物的表达，并发现在这种情况下引发了新的细胞和分子昼夜节律。内毒素特异的昼夜节律程序表现出独特的特征，包括与基础状态相比，一组不同的节律基因和代谢物，以及明显的周期性和相态分布。在细胞水平上，内毒素治疗也改变了肺内白细胞计数的昼夜节律，这种改变依赖于BMal1，使粒细胞而不是淋巴细胞成为主要的振荡细胞类型。我们的结果表明，炎症导致细胞和分子昼夜节律的复杂重组，这些节律与肺损伤的早期事件相关。
Circadian rhythms are known to regulate immune responses in healthy animals, but it is unclear whether they persist during acute illnesses where clock gene expression is disrupted by systemic inflammation. Here, we use a genome-wide approach to investigate circadian gene and metabolite expression in the lungs of endotoxemic mice and find that novel cellular and molecular circadian rhythms are elicited in this setting. The endotoxin-specific circadian program exhibits unique features, including a divergent group of rhythmic genes and metabolites compared to the basal state and a distinct periodicity and phase distribution. At the cellular level endotoxin treatment also alters circadian rhythms of leukocyte counts within the lung in a bmal1-dependent manner, such that granulocytes rather than lymphocytes become the dominant oscillating cell type. Our results show that inflammation produces a complex reorganization of cellular and molecular circadian rhythms that are relevant to early events in lung injury.
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DOI：
10.1073/pnas.1118726109
发表时间：
2012-04-03
影响因子：
11.1
作者：
Eckel-Mahan, Kristin L.;Patel, Vishal R.;Sassone-Corsi, Paolo
通讯作者：
Sassone-Corsi, Paolo
影响因子：
4.1
作者：
Jordan, Sabine D.;Lamia, Katja A.
通讯作者：
Lamia, Katja A.
影响因子：
4.8
作者：
Hwang, Jae-Woong;Sundar, Isaac K.;Rahman, Irfan
通讯作者：
Rahman, Irfan
影响因子：
10.5
作者：
Kondratov, Roman V.;Kondratova, Anna A.;Antoch, Marina P.
通讯作者：
Antoch, Marina P.
影响因子：
3.7
作者：
Kuipers, Maria T.;Aslami, Hamid;Wieland, Catharina W.
通讯作者：
Wieland, Catharina W.