Mechanisms of Photosensitivity in Autoimmunity.

Mechanisms of Photosensitivity in Autoimmunity.
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自身免疫中的光敏性机制。

DOI:
10.1016/j.jid.2021.05.007
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发表时间:
2022-03
期刊:
The Journal of investigative dermatology
影响因子:
--
通讯作者:
Kahlenberg JM
Kahlenberg JM
中科院分区:
其他
文献类型:
--
作者:
Estadt SN;Maz MP;Musai J;Kahlenberg JM

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在一些自身免疫性疾病中,对紫外线(UV)的异常反应经常导致皮肤病变的形成和系统性疾病的激活,特别是系统性红斑狼疮。虽然紫外线对皮肤的影响已经研究了几十年,但直到最近才发现一些导致自身免疫性疾病患者对紫外线异常反应的机制。本文将讨论紫外线在表皮的生物学,并讨论异常的表皮和炎症机制,有助于光敏性。需要进一步的研究来充分了解如何使自身免疫性患者的UV介导的炎症正常化。
Aberrant responses to ultraviolet (UV) light frequently lead to formation of skin lesions and activation of systemic disease in some autoimmune diseases, especially systemic lupus erythematosus. While the effects of UV light on the skin have been studied for decades, only recently have some of the mechanisms that contribute to abnormal responses to UV light in autoimmune disease patients been uncovered. This review will discuss the biology of UV in the epidermis and discuss the abnormal epidermal and inflammatory mechanisms that contribute to photosensitivity. Further research is required to fully understand how to normalize UV-mediated inflammation in autoimmune patients.
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