Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy.
Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy.
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DOI：
10.1016/j.bbcan.2011.01.001
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发表时间：
2011-04
影响因子：
11.2
通讯作者：
Batra, Surinder K.
中科院分区：
文献类型：
--
作者：
Mukhopadhyay, Partha;Chakraborty, Subhankar;Ponnusamy, Moorthy P.;Lakshmanan, Imayavaramban;Jain, Maneesh;Batra, Surinder K.
关键词：
粘蛋白是高分子量的多功能糖蛋白，由两种结构类型组成-大的跨膜粘蛋白和形成凝胶或分泌的粘蛋白。粘蛋白的主要功能是保护和润滑人体内上皮衬里的导管的管腔表面。最近的研究已经确定了与非肿瘤性乳腺组织相比，乳腺癌组织中膜结合粘蛋白（MUC 1、MUC 4和MUC 16）和分泌粘蛋白（MUC 2、MUC 5AC、MUC 5 B和MUC 6）的差异表达。功能研究也发现了粘蛋白在乳腺癌发展过程中的许多独特作用，包括调节肿瘤细胞的增殖、侵袭和转移潜能。粘蛋白通过许多独特的结构域发挥功能，这些结构域可以与包括生长因子受体和细胞间粘附分子在内的各种信号分子形成复杂的缔合。虽然有越来越多的信息粘蛋白在各种恶性肿瘤，包括乳腺癌，没有集中的审查是在乳腺癌中的表达和功能作用的粘蛋白。本文综述了粘蛋白在乳腺癌中的差异表达及其功能作用。粘蛋白作为诊断和预后标志物以及作为乳腺癌治疗靶点的潜力也已被讨论。
Mucins are high molecular weight; multifunctional glycoproteins comprised of two structural classes - the large transmembrane mucins and the gel-forming or secreted mucins. The primary function of mucins is to protect and lubricate the luminal surfaces of epithelium-lined ducts in the human body. Recent studies have identified a differential expression of both membrane bound (MUC1, MUC4 and MUC16) and secreted mucins (MUC2, MUC5AC, MUC5B and MUC6) in breast cancer tissues when compared with the non-neoplastic breast tissues. Functional studies have also uncovered many unique roles of mucins during the progression of breast cancer, which include modulation in proliferative, invasive and metastatic potential of tumor cells. Mucins function through many unique domains those can form complex association with various signaling molecules including growth factor receptors and intercellular adhesion molecules. While there is growing information about mucins in various malignancies including breast cancer, no focused review is there on the expression and functional roles of mucins in breast cancer. In this present review, we have discussed the differential expression and functional roles of mucins in breast cancer. The potential of mucins as diagnostic and prognostic markers and as therapeutic targets in breast cancer have also been discussed.
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影响因子：
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