The Associations of Fruit and Vegetable Intake with Lung Cancer Risk in Participants with Different Smoking Status: A Meta-Analysis of Prospective Cohort Studies
The Associations of Fruit and Vegetable Intake with Lung Cancer Risk in Participants with Different Smoking Status: A Meta-Analysis of Prospective Cohort Studies
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不同吸烟状况参与者的水果和蔬菜摄入量与肺癌风险的关联：前瞻性队列研究的荟萃分析
作者：
Wang Chong;Yang Ting;Guo Xiao fei;Li Duo
关于水果和蔬菜摄入量与肺癌风险关系的流行病学研究结果在不同吸烟状况的参与者中不一致。本研究的目的是通过前瞻性队列研究，在不同吸烟状态的参与者中调查这些关系。使用截至2019年6月的PubMed和Scopus数据库进行了系统性文献检索。采用随机效应模型计算总体相对危险度（RR）和95%可信区间（CI）。采用约束三次样条回归模型进行非线性剂量反应分析。使用Begg检验估计发表偏倚。纳入了9项独立的前瞻性研究进行数据合成。在吸烟者和既往吸烟者中，水果摄入量与肺癌风险呈负相关，夏季RR分别为0.86（95%CI：0.78，0.94）和0.91（95%CI：0.84，0.99）。对于目前吸烟者，蔬菜消费与肺癌风险降低显著相关（汇总RR = 87%; 95%CI：0.78，0.94），但对于既往吸烟者和吸烟者则无相关性。剂量反应分析表明，每天增加100克水果摄入量，目前吸烟者肺癌风险降低5%（95%CI：0.93，0.97），既往吸烟者肺癌风险降低4%（95%CI：0.93，0.98）。此外，剂量反应分析表明，目前吸烟者每天增加100克蔬菜摄入量，肺癌风险降低3%（95%CI：0.96，1.00）。这项研究的结果提供了强有力的证据，表明在当前吸烟者和前吸烟者中，较高的水果摄入量与肺癌风险呈负相关，而蔬菜摄入量与降低当前吸烟者的肺癌风险显著相关。这些发现可能对通过饮食干预预防肺癌具有相当大的公共卫生意义。
The results of epidemiological studies on the relationship between fruit and vegetable intake and lung cancer risk were inconsistent among participants with different smoking status. The purpose of this study was to investigate these relationships in participants with different smoking status with prospective cohort studies. A systematic literature retrieval was conducted using PubMed and Scopus databases up to June 2019. The summary relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were calculated by random-effects model. The nonlinear dose-response analysis was carried out with restricted cubic spline regression model. Publication bias was estimated using Begg’s test. Nine independent prospective studies were included for data synthesis. Dietary consumption of fruit was negatively correlated with lung cancer risk among current smokers and former smokers, and the summery RRs were 0.86 (95% CI: 0.78, 0.94) and 0.91 (95% CI: 0.84, 0.99), respectively. Consumption of vegetable was significantly associated with reduced risk of lung cancer for current smokers (summary RR = 87%; 95% CI: 0.78, 0.94), but not for former smokers and never for smokers. Dose-response analysis suggested that risk of lung cancer was reduced by 5% (95% CI: 0.93, 0.97) in current smokers, and reduced by 4% (95% CI: 0.93, 0.98) in former smokers with an increase of 100 grams of fruit intake per day, respectively. Besides, dose-response analysis indicated a 3% reduction in lung cancer risk in current smokers for 100 gram per day increase of vegetable intake (95% CI: 0.96, 1.00). The findings of this study provide strong evidence that higher fruit consumption is negatively associated with the risk of lung cancer among current smokers and former smokers, while vegetable intake is significantly correlated with reducing the risk of lung cancer in current smokers. These findings might have considerable public health significance for the prevention of lung cancer through dietary interventions.
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影响因子：
2.3
作者：
Buchner, F. L.;Bueno-de-Mesquita, H. B.;Linseisen, J.;Boshuizen, H. C.;Kiemeney, L. A. L. M.;Ros, M. M.;Overvad, K.;Hansen, L.;Tjonneland, A.;Raaschou-Nielsen, O.;Clavel-Chapelon, F.;Boutron-Ruault, M. -C.;Touillaud, M.;Kaaks, R.;Rohrmann, S.;Boeing, H.;Noethlings, U.;Trichopoulou, A.;Zylis, D.;Dilis, V.;Palli, D.;Sieri, S.;Vineis, P.;Tumino, R.;Panico, S.;Peeters, P. H. M.;van Gils, C. H.;Lund, E.;Gram, I. T.;Braaten, T.;Martinez, C.;Agudo, A.;Arriola, L.;Ardanaz, E.;Navarro, C.;Rodriguez, L.;Manjer, J.;Wirfalt, E.;Hallmans, G.;Rasmuson, T.;Key, T. J.;Roddam, A. W.;Bingham, S.;Khaw, K. -T.;Slimani, N.;Bofetta, P.;Byrnes, G.;Norat, T.;Michaud, D.;Riboli, E.
通讯作者：
Riboli, E.
DOI：
10.1158/1940-6207.capr-10-0384
发表时间：
2011-08
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Liu C;Bronson RT;Russell RM;Wang XD
通讯作者：
Wang XD
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
DOI：
--
发表时间：
2013
期刊：
--
影响因子：
--
作者：
A. Wyss;M. Hashibe;Shu-Chun Chuang;Y. Lee;Zuo‐Feng Zhang;Guo-Pei Yu;D. Winn;Q. Wei;R. Talamini-R.-Talam
通讯作者：
A. Wyss;M. Hashibe;Shu-Chun Chuang;Y. Lee;Zuo‐Feng Zhang;Guo-Pei Yu;D. Winn;Q. Wei;R. Talamini-R.-Talam
DOI：
10.3724/sp.j.1008.2015.01117
发表时间：
2015
影响因子：
--
作者：
Chong Ni;Shi-chang Guo;Yan Du;G. Cao
通讯作者：
Chong Ni;Shi-chang Guo;Yan Du;G. Cao