Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
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DOI：
10.1007/s10552-009-9468-y
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发表时间：
2010-03
影响因子：
2.3
通讯作者：
Riboli, E.
中科院分区：
文献类型：
--
作者：
Buchner, F. L.;Bueno-de-Mesquita, H. B.;Linseisen, J.;Boshuizen, H. C.;Kiemeney, L. A. L. M.;Ros, M. M.;Overvad, K.;Hansen, L.;Tjonneland, A.;Raaschou-Nielsen, O.;Clavel-Chapelon, F.;Boutron-Ruault, M. -C.;Touillaud, M.;Kaaks, R.;Rohrmann, S.;Boeing, H.;Noethlings, U.;Trichopoulou, A.;Zylis, D.;Dilis, V.;Palli, D.;Sieri, S.;Vineis, P.;Tumino, R.;Panico, S.;Peeters, P. H. M.;van Gils, C. H.;Lund, E.;Gram, I. T.;Braaten, T.;Martinez, C.;Agudo, A.;Arriola, L.;Ardanaz, E.;Navarro, C.;Rodriguez, L.;Manjer, J.;Wirfalt, E.;Hallmans, G.;Rasmuson, T.;Key, T. J.;Roddam, A. W.;Bingham, S.;Khaw, K. -T.;Slimani, N.;Bofetta, P.;Byrnes, G.;Norat, T.;Michaud, D.;Riboli, E.
关键词：
在欧洲癌症和营养前瞻性研究的参与者中，研究水果和蔬菜的摄入与不同组织学亚型肺癌风险之间的关系。采用多变量COX比例风险模型对数据进行分析。在亚样本中的校准研究被用来减少饮食测量误差。在平均8.7年的随访中，共发现1830例肺癌病例(腺癌574例，小细胞286例，大细胞137例，鳞状细胞363例，其他组织学470例)。与我们之前的结论一致，我们发现在校正后，每天增加100微克水果和蔬菜的摄入量与降低肺癌风险相关(HR为0.94；95%CI为0.89-0.99)。在现在的吸烟者中也发现了这种情况(HR为0.93；95%CI为0.90-0.97)。目前吸烟者患鳞状细胞癌的风险降低，水果和蔬菜加在一起每天增加100微克(HR 0.85；95%CI 0.76-0.94)，而对其他组织学亚型没有明显影响。我们观察到蔬菜和水果的摄入与肺癌风险呈负相关，而对肺癌的特定组织学亚型没有明显的影响。在目前的吸烟者中，食用蔬菜和水果可能会降低患肺癌的风险，特别是患鳞状细胞癌的风险。
To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study. Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors. During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced lung cancer risk (HR 0.94; 95% CI 0.89–0.99). This was also seen among current smokers (HR 0.93; 95% CI 0.90–0.97). Risks of squamous cell carcinomas in current smokers were reduced for an increase of 100 g/day of fruit and vegetables combined (HR 0.85; 95% CI 0.76–0.94), while no clear effects were seen for the other histological subtypes. We observed inverse associations between the consumption of vegetables and fruits and risk of lung cancer without a clear effect on specific histological subtypes of lung cancer. In current smokers, consumption of vegetables and fruits may reduce lung cancer risk, in particular the risk of squamous cell carcinomas.
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影响因子：
9.6
作者：
Khuder, SA;Mutgi, AB
通讯作者：
Mutgi, AB
影响因子：
5.3
作者：
Khuder, SA
通讯作者：
Khuder, SA
DOI：
10.1111/j.1349-7006.2001.tb02148.x
发表时间：
2001-12
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Ozasa K;Watanabe Y;Ito Y;Suzuki K;Tamakoshi A;Seki N;Nishino Y;Kondo T;Wakai K;Ando M;Ohno Y
通讯作者：
Ohno Y
影响因子：
10.3
作者：
Feskanich, D;Ziegler, RG;Colditz, GA
通讯作者：
Colditz, GA
DOI：
10.1093/jnci/91.2.182
发表时间：
1999-01-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Knekt, P;Järvinen, R;Seppänen, R
通讯作者：
Seppänen, R