Prognostic importance of the inflammation-based Glasgow prognostic score in patients with gastric cancer.
Prognostic importance of the inflammation-based Glasgow prognostic score in patients with gastric cancer.
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DOI：
10.1038/bjc.2012.262
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发表时间：
2012-07-10
影响因子：
8.8
通讯作者：
Yamaguchi, T.
中科院分区：
文献类型：
--
作者：
Jiang, X.;Hiki, N.;Nunobe, S.;Kumagai, K.;Kubota, T.;Aikou, S.;Sano, T.;Yamaguchi, T.
基于炎症的格拉斯哥预后评分（GPS）已被证明是多种肿瘤的预后因素。本研究旨在探讨改良GPS（mGPS）对胃癌患者预后的意义。根据2000年1月至2007年12月期间接受手术的1710例胃癌患者的术前数据计算mGPS（0= C反应蛋白（CRP）<10 mg l−1，1=CRP> 10 mg l −1和2=CRP>10 mg l −1和白蛋白<35 g l−1）。患者的mGPS为0、1或2。单因素和多因素分析其预后意义。mGPS升高与男性患者、老年、低体重指数、白色细胞计数和中性粒细胞计数升高、癌胚抗原和CA 19 -9升高以及肿瘤分期晚期相关。Kaplan-Meier分析和log-rank检验显示，在相对早期（I期; P<0.001）和晚期癌症（II、III和IV期; P<0.001）中，较高的mGPS预测较高的术后死亡风险。多变量分析表明，mGPS是术后死亡率的危险因素（比值比1.845; 95%置信区间1.184-2.875; P=0.007）。术前mGPS是预测胃癌患者术后生存的一个简单而有用的指标。
The inflammation-based Glasgow prognostic score (GPS) has been shown to be a prognostic factor for a variety of tumours. This study investigates the significance of the modified GPS (mGPS) for the prognosis of patients with gastric cancer. The mGPS (0=C-reactive protein (CRP)⩽10 mg l−1, 1=CRP>10 mg l−1 and 2=CRP>10 mg l−1 and albumin<35 g l−1) was calculated on the basis of preoperative data for 1710 patients with gastric cancer who underwent surgery between January 2000 and December 2007. Patients were given an mGPS of 0, 1 or 2. The prognostic significance was analysed by univariate and multivariate analyses. Increased mGPS was associated with male patient, old age, low body mass index, increased white cell count and neutrophils, elevated carcinoembryonic antigen and CA19-9 and advanced tumour stage. Kaplan–Meier analysis and log-rank test revealed that a higher mGPS predicted a higher risk of postoperative mortality in both relative early-stage (stage I; P<0.001) and advanced-stage cancer (stage II, III and IV; P<0.001). Multivariate analysis demonstrated the mGPS to be a risk factor for postoperative mortality (odds ratio 1.845; 95% confidence interval 1.184–2.875; P=0.007). The preoperative mGPS is a simple and useful prognostic factor for postoperative survival in patients with gastric cancer.
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