Engineered chimeric antigen receptor-expressing T cells for the treatment of pancreatic ductal adenocarcinoma.

Engineered chimeric antigen receptor-expressing T cells for the treatment of pancreatic ductal adenocarcinoma.
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设计的嵌合抗原受体T细胞用于治疗胰腺导管腺癌。

DOI:
10.4161/onci.28327
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发表时间:
2014
期刊:
影响因子:
7.2
通讯作者:
Beatty GL
Beatty GL
中科院分区:
医学2区
文献类型:
--
作者:
Beatty GL

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正在研究使用嵌合抗原受体(CAR)工程化T细胞的免疫细胞疗法作为恢复胰腺导管腺癌患者中的生产性T细胞免疫监视的方法。早期研究结果证明了这种基于细胞的疗法的安全性和CAR表达T细胞介导抗肿瘤活性以及诱导内源性抗肿瘤免疫应答的能力。
Adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells is under investigation as an approach to restore productive T cell immunosurveillance in patients with pancreatic ductal adenocarcinoma. Early findings demonstrate safety of this cell-based therapy and the capacity of CAR-expressing T cells to mediate anti-tumor activity as well as induce endogeneous antitumoral immune responses.
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