Obesity in C57BL/6J mice fed diets differing in carbohydrate and fat but not energy content.
Obesity in C57BL/6J mice fed diets differing in carbohydrate and fat but not energy content.
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DOI：
10.1016/j.physbeh.2021.113644
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发表时间：
2022-01-01
影响因子：
2.9
通讯作者：
Ellis HT
中科院分区：
文献类型：
--
作者：
Tordoff MG;Ellis HT
为了探讨碳水化合物和脂肪在肥胖中的作用，我们测量了成年C57BL/6J小鼠的体重、体成分和摄食量，其中随机饲喂了两种碳水化合物和脂肪含量不同但蛋白质、微量营养素和能量含量不同的半合成饲料。在实验1中，雄性小鼠的体重与饲喂(按能量计算)20%蛋白质、75%碳水化合物和5%脂肪(C75-F5)或20%蛋白质、5%碳水化合物和75%脂肪(C5-F75)的饲料组相似。然而，喂食50：50 C75-F5和C5-F75饮食(即C40-F40饮食)的小鼠变得更加肥胖。可以在C75-F5和C5-F75饮食中选择的小鼠摄入了每种饮食中相同数量的食物，并且体重增加的程度几乎与喂养C40-F40饮食的那一组相同。每天在C75-F5和C5-F75饮食之间切换的小鼠的体重并不比只喂其中一种饮食的小鼠增加的体重更多。在实验2中，雄性和雌性小鼠被喂食食物或8种碳水化合物和脂肪含量不同的等热量饮食中的一种。与那些碳水化合物和脂肪比例更高的饮食(例如，C75-F5，C5-F75)相比，在摄取适中范围的食物(即C35-F45或C45-F35)的小组中，体重和脂肪显著增加，这一影响在男性中比女性更明显。在实验3和实验4中，喂食C40-F40配方的雄性小鼠比喂食C75-F5或C5-F75配方的雄性小鼠增加了更多的体重，无论碳水化合物主要是蔗糖还是主要是淀粉，或者脂肪是植物油、玉米油、棕榈油或菜籽油；碳水化合物或脂肪的类型对体重影响很小或没有影响。在所有四个实验中，不同饮食组的能量摄入量不同，但不能解释体重的差异。这些结果表明，饮食中碳水化合物和脂肪的比例独立于能量含量影响体重，碳水化合物或脂肪的类型对体重影响很小。同时或近距离摄入碳水化合物和脂肪会加剧肥胖。
To investigate the contributions of carbohydrate and fat to obesity we measured the body weight, body composition and food intake of adult C57BL/6J mice fed ad libitum with various combinations of two semisynthetic diets that differed in carbohydrate and fat but not in protein, micronutrient or energy content. In Experiment 1, involving male mice, body weights were similar in groups fed diets comprised of (by energy) 20% protein, 75% carbohydrate and 5% fat (C75-F5) or 20% protein, 5% carbohydrate and 75% fat (C5-F75). However, mice fed a 50:50 composite mixture of the C75-F5 and C5-F75 diets (i.e., a C40-F40 diet) became substantially more obese. Mice that could choose between the C75-F5 and C5-F75 diets ate equal amounts of each diet and gained almost as much weight as did the group fed C40-F40 diet. Mice switched every day between the C75-F5 and C5-F75 diets gained no more weight than did those fed either diet exclusively. In Experiment 2, male and female mice were fed chow or one of 8 isocaloric diets that differed parametrically in carbohydrate and fat content. Groups fed diets in the middle of the range (i.e., C35-F45 or C45-F35) weighed significantly more and were significantly fatter than were those fed diets with more extreme proportions of carbohydrate and fat (e.g., C75-F5, C5-F75), an effect that was more pronounced in males than females. In Experiment 3 and 4, male mice fed versions of the C40-F40 formulation gained more weight than did those fed the C75-F5 or C5-F75 formulations irrespective of whether the carbohydrate was predominantly sucrose or predominantly starch, or whether the fat was vegetable shortening, corn oil, palm oil or canola oil; the type of carbohydrate or fat had little or no impact on body weight. In all four experiments, energy intakes differed among the diet groups but could not account for the differences in body weight. These results demonstrate that the proportion of carbohydrate and fat in the diet influences body weight independently of energy content, and that the type of carbohydrate or fat has little impact on body weight. Consuming carbohydrate and fat simultaneously or in close temporal proximity exacerbates obesity.
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影响因子：
29
作者：
Chaix A;Lin T;Le HD;Chang MW;Panda S
通讯作者：
Panda S
影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S
影响因子：
8.1
作者：
Hu, Sumei;Wang, Lu;Speakman, John R.
通讯作者：
Speakman, John R.
DOI：
10.1152/ajpendo.00332.2001
发表时间：
2002-04-01
影响因子：
5.1
作者：
Burcelin, M;Crivelli, V;Thorens, B
通讯作者：
Thorens, B
影响因子：
2.4
作者：
EDWARDS, DG;PORTER, PD;DEAN, J
通讯作者：
DEAN, J