"Environmental risk factors associated with juvenile idiopathic arthritis associated uveitis: a systematic review of the literature".
"Environmental risk factors associated with juvenile idiopathic arthritis associated uveitis: a systematic review of the literature".
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DOI：
10.1186/s12348-021-00247-1
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发表时间：
2021-05-24
影响因子：
2.9
通讯作者：
Ramanan AV
中科院分区：
文献类型：
--
作者：
Clarke SLN;Mageean KS;Carlton H;Simonini G;Sharp GC;Relton CL;Ramanan AV
幼年特发性关节炎相关性葡萄膜炎（JIA-U）是幼年特发性关节炎（JIA）最常见的关节外表现，对视力有相当大的风险。本系统评价的目的是综合JIA-U的环境风险因素的证据，并确定可能是可修改的或用于对JIA患者进行分层的风险因素。本系统评价按照PRISMA指南进行。检索了4个在线数据库-护理和相关健康文献累积索引、Web of Science、MEDLINE和Embase -从数据库开始到2020年8月12日。确定的研究由两名独立的审查员根据预先定义的纳入和排除标准进行筛选。从符合入选标准的所有主要研究中提取数据，并进行独立检查。我们从895个符合纳入标准的独特记录中确定了三项研究，每项研究都检查了不同的环境风险因素。这项系统性综述包括这三项研究中的973名JIA受试者，主要是女性。在所有模型中，使用过敏药物或在病历中记录“过敏”/“过敏”与JIA-U风险增加相关。维生素D充足与JIA-U风险降低相关。没有足够的证据支持季节性和JIA-U之间的关联。本文综述了过敏和维生素D在JIA-U中的潜在作用。它还说明了缺乏有关环境风险因素的数据JIA-U，并强调需要进一步的研究，以确定额外的风险因素和复制现有的研究结果。
Juvenile idiopathic arthritis associated uveitis (JIA-U) is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA) and carries considerable risk to vision. The aim of this systematic review was to synthesise evidence of environmental risk factors for JIA-U and identify risk factors which may be modifiable or used to stratify JIA patients. This systematic review was carried out in accordance with PRISMA guidelines. Four online databases - Cumulative Index of Nursing and Allied Health Literature, Web of Science, MEDLINE and Embase - were searched from database inception to 12th August 2020. Identified studies were screened by two independent reviewers against pre-defined inclusion and exclusion criteria. Data was extracted from all primary studies meeting inclusion criteria and independently checked. We identified three studies from 895 unique records which met the inclusion criteria, each examining a different environmental risk factor. This systematic review includes 973, predominantly female, participants with JIA across these three studies. The use of allergy medication or documentation of “allergy”/“allergic” in the medical records was associated with an increased risk of JIA-U in all models presented. Vitamin D sufficiency was associated with reduced risk of JIA-U. There was insufficient evidence to support an association between seasonality and JIA-U. This review identifies a potential role for allergy and vitamin D in JIA-U. It also illustrates the paucity of data regarding environmental risk factors for JIA-U and highlights the need for further research to both identify additional risk factors and replicate existing findings.
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影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
Prahalad, Sampath
影响因子：
13.7
作者：
Kotaniemi, K;Kautiainen, H;Aho, K
通讯作者：
Aho, K